The journal of nutrition, health & aging

, Volume 23, Issue 4, pp 318–322 | Cite as

Association Between Orthostatic Hypotension and Frailty in Hospitalized Older Patients: A Geriatric Syndrome More Than a Cardiovascular Condition

  • L. Chen
  • Y. Xu
  • Xujiao ChenEmail author
  • Wei-Ju LeeEmail author
  • L.-K. Chen



To explore the association between orthostatic hypotension (OH) and frailty for hospitalized older patients and their vulnerable subgroups.


A prospective, observational cross-sectional study.


693 older patients admitted to a geriatric evaluation and management unit.


Barthel Index, Lawton’s instrumental activities of daily living, clinical frailty scale, mini-mental state examination, geriatric depression scale, mini-nutritional assessment, and polypharmacy.


Overall, the prevalence of OH and frailty was 26% and 36%, respectively. Subjects with OH were older, thinner, more commonly to have weakness, slowness, poorer physical function and higher levels of frailty. The prevalence of OH was substantially increased as higher levels of CFS (p for trend <0.001). Multivariate logistic regression showed significant association between OH and frailty (OR: 1.8, 95% CI: 1.2-2.7), but the association attenuated after adjustment for physical function. (OR: 1.4, 95% CI: 0.7-2.6). Nevertheless, associations between OH and frailty remained significant among vulnerable subgroups like women, subjects having weakness, slowness, poor cognitive function, polypharmacy or any IADL limitation.


OH in hospitalized older patients was associated with frailty and multiple complex care needs, especially in the vulnerable subgroups. Further study is needed to clarify the roles of OH in clinical practice.

Key words

Frailty older adults orthostatic hypotension comprehensive geriatric assessment 


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Copyright information

© Serdi and Springer-Verlag International SAS, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NursingZhejiang HospitalHangzhou, Zhejiang ProvincePeople’s Republic of China
  2. 2.Department of GeriatricsZhejiang HospitalHangzhou, Zhejiang ProvincePeople’s Republic of China
  3. 3.Aging and Health Research CenterNational Yang Ming UniversityTaipeiTaiwan
  4. 4.Department of Geriatric Medecine, School of MedicineNational Yang-Ming UniversityTaipei CityTaiwan
  5. 5.Department of Family MedicineTaipei Veterans General Hospital YuanShan Branch, Yi-Lan CountyTaipeiTaiwan
  6. 6.Center for Geriatrics and GerontologyTaipei Veterans General HospitalTaipeiTaiwan

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