The journal of nutrition, health & aging

, Volume 22, Issue 8, pp 944–951 | Cite as

Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial

  • D. H. Yoon
  • Jun-Young LeeEmail author
  • Wook SongEmail author



Cognitive frailty is defined as the presence of both physical frailty and cognitive impairment (clinical dementia rating score = 0.5), in the absence of dementia. It is characterized by concurrent physical frailty and potentially reversible cognitive impairment. In this study, we sought to elucidate the effects of high-speed resistance exercise training on cognitive function and physical performance in older adults with cognitive frailty.


We conducted a parallel-group, randomized controlled trial involving community-living older adults with cognitive frailty. The participants’ mean age was 73.9 (± 4.3 SD) years, and 69.8% (n=30) were female. Two different 4-month interventions included high-speed resistance exercise training group (n=22) and a control group (balance and band stretching, n=23). Frailty score, cognitive function (memory, processing speed, cognitive flexibility, working memory, executive function), physical function (SPPB, TUG, gait speed), and muscle strength (grip strength, knee extension strength) were assessed at baseline, 8 weeks, and 16 weeks.


Statistical analysis showed that exercise improved performance significantly in the tests for cognitive function (processing speed and executive function, both p < 0.05), physical function (SPPB, TUG, gait speed, both p < 0.05), and muscle strength (grip strength, knee extension strength, both p < 0.05). However, no significant changes in frailty score were observed between intervention and either control group (p < 0.05).


In conclusion, our findings indicate that high-speed resistance exercise training approaches are effective in improving cognitive function and physical performance in older adults with cognitive frailty. This study shows that it is feasible to identify older adults with cognitive frailty in the community and primary care setting for effective intervention to reduce their level of frailty and cognitive impairment.

Key words

Cognitive frailty mild cognitive impairment physical frailty resistance training randomized clinical trials 


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Copyright information

© Serdi and Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Health and Exercise Science, Institute of Sports ScienceSeoul National UniversitySeoulKorea
  2. 2.Institute on AgingSeoul National UniversitySeoulKorea
  3. 3.Department of Psychiatry and Behavioral ScienceSMG-SNVU Boramaero Medical CenterSeoulKorea
  4. 4.Department of Psychiatry and Behavioral ScienceSeoul National University College of MedicineSeoulKorea
  5. 5.Institute of Sports Science, Health and Exercise Science LaboratorySeoul National UniversitySeoulKorea
  6. 6.Department of Psychiatry and Neuroscience Research InstituteSeoul National University College of Medicine. SMG-SNU Boramae Medical CenterSeoulKorea

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