The effect of 5-HT1A receptor antagonist on reward-based decision-making

  • Fumika Akizawa
  • Takashi Mizuhiki
  • Tsuyoshi Setogawa
  • Mai Takafuji
  • Munetaka ShidaraEmail author
Original Paper


When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin (5-HT) level tend to choose smaller immediate reward. We used a decision-making schedule task to investigate whether 5-HT1A receptor is responsible for the decisions related to reward. In this task, the monkeys chose either of two different alternatives that were comprised of 1–4 drops of liquid reward (benefit) and 1–4 repeats of a color discrimination trial (workload cost), then executed the chosen schedule. By the administration of 5-HT1A antagonist, WAY100635, the choice tendency did not change, however, the sensitivity to the amount of reward in the schedule part was diminished. The 5-HT1A could have a role in maintaining reward value to keep track with the promised reward rather than modulating workload discounting of reward value.


5-HT1A Value discounting WAY100635 Decision-making Workload Rhesus monkey 



This work was supported by Grant-in-Aid for JSPS Fellows (Grant Number JP15J00709) (FA); Grant-in-Aid for Scientific Research on Priority Areas-System study on higher order brain functions from MEXT of Japan (Grant Number JP17022052) (MS) and JSPS KAKENHI Grant Numbers JP22300138, JP25282246, JP16H03301 (MS); JSPS KAKENHI Grant Number JP26119504 (TM).

Author contributions

FA and TM contributed equally to this work. FA, TM, and MS designed the experiment. FA, TS, TM, and MT performed experiment. FA and TM analyzed behavioral and pharmacological data. FA, TM, and MS wrote the manuscript and created all figures. FA, TM, TS, and MS discussed the data.

Compliance with ethical standards

Conflict of interest

The authors declare no competing financial interests.

Ethical approval

All experimental procedures were approved by Animal Care and Use Committee of the University of Tsukuba, and were in accordance with the Guide for the Care and Use of Laboratory Animals in the University of Tsukuba.


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Copyright information

© The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Doctoral Program in Kansei, Behavioral and Brain Science, Graduate School of Comprehensive Human SciencesUniversity of TsukubaTsukubaJapan
  2. 2.Faculty of MedicineUniversity of TsukubaTsukubaJapan

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