Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration
- 81 Downloads
Statins and exercise reduce cardiovascular disease incidence. We investigated whether endurance exercise in mice induces mitochondrial adaptation in skeletal muscle and muscle injury during administration of atorvastatin, a member of the statin medication class. Male C57BL mice were assigned to one of three groups: control (Con), statin (Statin), or statin and exercise (Statin + Ex). Atorvastatin was administered, and exercise performed on a treadmill for 8 weeks. The levels of mitochondria-associated proteins, PGC-1α, and respiratory chain complex, (COX) I–V, in the quadriceps femoris, and serum creatine kinase, a muscle injury marker, were measured. PGC-1α and COX I–V were upregulated in the Statin + Ex group compared to those in the Statin and Con groups; serum creatine kinase levels were similar. Endurance training in mice induced mitochondrial adaptation in skeletal muscle without causing muscle injury, during atorvastatin administration.
KeywordsStatin Exercise PGC-1α Respiratory chain complexes Muscle injury
We would like to thank Editage (www.editage.jp) for English language editing.
KN contributed to experimental design, data collection, analysis, and manuscript preparation. YO contributed to experimental design and data collection. KI contributed to experimental design and manuscript preparation. MS, SU, and JA contributed to manuscript preparation.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution at which the studies were conducted.
- 1.Endo A (1992) The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 33:1569–1582Google Scholar
- 11.Nakayama A, Aoi W, Takami M, Hirano N, Ogaya Y, Wada S, Higashi A (2018) Effect of downhill walking on next-day muscle damage and glucose metabolism in healthy young subjects. J Physiol Sci 20:1–8Google Scholar
- 17.Lira V, Benton C, Yan Z, Bonen A (2010) PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol 299:E145–E161Google Scholar