The Journal of Physiological Sciences

, Volume 68, Issue 4, pp 521–530 | Cite as

Effects of voluntary exercise on antiretroviral therapy-induced neuropathic pain in mice

  • Hong Ye
  • Xingguang Du
  • Qingli HuaEmail author
Original Paper


Antiretroviral therapy (ART) often results in painful peripheral neuropathy. Given that voluntary exercise has been shown to be beneficial in terms of modulating pain-like behaviors in various animal models of peripheral neuropathy, we have investigated the effects of voluntary wheel running on neuropathic pain induced by chronic ART. We first established an animal model of peripheral neuropathy induced by chronic 2′,3′-dideoxycytidine (ddC) treatment. We showed that mice receiving ddC (3 mg/kg/day) had increased mechanical and thermal sensitivity at 9 weeks after the onset of the treatment. We also found that voluntary wheel running attenuated or delayed the onset of ddC-induced peripheral neuropathy. This phenomenon was associated with the attenuation of dorsal root ganglion nociceptive neuron membrane excitability and reduction in the expression of the transient receptor potential cation channel subfamily V member 1 (TRPV1). Taken together, these results suggest that voluntary exercise is an effective strategy by which ART-induced peripheral neuropathy can be alleviated.


Antiretroviral therapy Peripheral neuropathy Dorsal root ganglion Nociceptive neuron TRPV1 


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Research involving human/animal participants

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.




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Copyright information

© The Physiological Society of Japan and Springer Japan KK 2017

Authors and Affiliations

  1. 1.Department of AnesthesiologyDaqing Oil Field General HospitalDaqingChina
  2. 2.Department of AnesthesiologyDaqing Longnan HospitalDaqingChina

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