The Journal of Physiological Sciences

, Volume 68, Issue 4, pp 455–462 | Cite as

Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

  • Yukyung Lee
  • Gaeun Choi
  • Hyongjun Jeon
  • Dongsoo Kim
  • Sun Ryu
  • Sungtae Koo
  • Ki-Tae Ha
  • Seungtae KimEmail author
Original Paper


Recent studies have suggested that increased oxidative stress is a potential etiology in Parkinson’s disease (PD). In this study, we investigated whether acupuncture regulates antioxidants in the striatum (ST) of a PD mouse model. Male C57BL/6 mice were administered 30 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneally once a day for 5 days and given acupuncture stimulation at SI3 or GB34 (Yanglingquan) was for 12 consecutive days. Dopaminergic neuronal survival in the nigrostriatal pathway and DJ-1 expression in the ST was evaluated by immunostaining, and the activities of superoxide dismutase (SOD) and catalase (CAT) in the ST was by enzyme-linked immunosorbent assay. MPTP administration induced dopaminergic neuronal death in the nigrostriatal pathway, which was suppressed by acupuncture stimulation at GB34. MPTP administration also suppressed DJ-1 expression and SOD and CAT activities in the ST, which were restored by acupuncture stimulation at GB34. These results indicate that the neuroprotective effect of acupuncture stimulation is due to regulation of the antioxidants.


Parkinson’s disease Acupuncture Antioxidant DJ-1 Superoxide dismutase Catalase 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 



This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2014R1A5A2009936).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© The Physiological Society of Japan and Springer Japan 2017

Authors and Affiliations

  1. 1.Division of Meridian and Structural Medicine, School of Korean MedicinePusan National UniversityYangsan-siRepublic of Korea
  2. 2.Korean Medicine Research Center for Healthy AgingPusan National UniversityYangsan-siRepublic of Korea

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