The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes
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Oxidative stress contributes to the progression of neurodegenerative diseases of the central and peripheral nervous systems, including Alzheimer’s disease, Parkinson’s disease, stroke, and diabetic neuropathy. Despite the greater capability of peripheral nerves to regenerate compared with those in the brain or spinal cord, chronic oxidative stress leads to irreversible neurodegeneration in peripheral nerves. Thus, many efforts have been made to defend against irreversible peripheral nerve degeneration and oxidative stress. Numerous phytochemicals have been revealed as antioxidants which neutralize free radicals and reduce peripheral neurocellular damage. Among them, polyphenols alleviate neurodegeneration by interacting with reactive oxygen species. Apigenin is a polyphenol found in plant-derived foods, including parsley, thyme, celery, and chamomile tea. Apigenin has been reported to exert antioxidative effects by scavenging free radicals. In particular, apigenin has a neuroprotective effect against oxidative stress in neurological disorders, such as cerebral ischemia. However, to date, no studies have shown an association of the inhibitory effect of apigenin with peripheral nerve degeneration. In this work, we showed that apigenin has a neuroprotective effect against peripheral nerve degeneration according to four key phenotypes: axonal degradation, myelin fragmentation, trans-dedifferentiation, and proliferation of Schwann cells via Krox20- and extracellular signal-regulated kinase-independent processes. Thus, apigenin could be a good candidate to treat peripheral neurodegenerative diseases.
KeywordsApigenin Antioxidant Schwann cells Demyelination Axonal degeneration
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT) (N.Y. Jeong, 2018R1A2B6001123; J. Jung, 2018R1D1A1B07040282; H.J. Chung, 2018R1C1B5029745).
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Conflict of interest
The authors declare that there are no conflicts of interest.
- Mao X-Y, Yu J, Liu Z-Q, Zhou H-H (2015) Apigenin attenuates diabetes-associated cognitive decline in rats via suppressing oxidative stress, nitric oxide synthase and anti-apoptotic pathway. Int J Clin Exp Med 8:15506–15513Google Scholar
- Patel D, Shukla S, Gupta S (2007) Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol 30:233–245Google Scholar
- Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA (1994) Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J Biol Chem 269:26066–26075Google Scholar
- Santin Y, Sicard P, Vigneron F, Guilbeau-Frugier C, Dutaur M, Lairez O, Couderc B, Manni D, Korolchuk VI, Lezoualc’h F, Parini A, Mialet-Perez J, (2016) Oxidative stress by monoamine oxidase-a impairs transcription factor EB activation and autophagosome clearance, leading to cardiomyocyte necrosis and heart failure. Antioxid Redox Signal 25:10–27CrossRefGoogle Scholar
- Wu F, Yao H, Zheng F, Tang S, Lin X, Li L, Zhou J, Li H (2018) Protective effects of honokiol against oxidative stress-induced apoptotic signaling in mouse podocytes treated with H2O2. Exp Ther Med 16:1278–1284Google Scholar