Mechanobiology of cells and cell systems, such as organoids

  • Ece Bayir
  • Aylin Sendemir
  • Yannis F. MissirlisEmail author


Organoids are in vitro 3D self-organizing tissues that mimic embryogenesis. Organoid research is advancing at a tremendous pace, since it offers great opportunities for disease modeling, drug development and screening, personalized medicine, as well as understanding organogenesis. Mechanobiology of organoids is an unexplored area, which can shed light to several unexplained aspects of self-organization behavior in organogenesis. It is becoming evident that collective cell behavior is distinctly different from individual cells’ conduct against certain stimulants. Inherently consisting of higher number of degrees of freedom for cell motility and more complex cell-to-cell and cell-to-extracellular matrix behavior, understanding mechanotransduction in organoids is even more challenging compared with cell communities in 2D culture conditions. Yet, deciphering mechanobiology of organoids can help us understand effects of mechanical cues in health and disease, and translate findings of basic research toward clinical diagnosis and therapy.


Organoid Mechanobiology Mechanoepigenetics Mechanotransduction Collective cell behavior 



The authors acknowledge COST Action 16122 (BIONECA) for financing Prof. Dr. Yannis F. Missirlis for an STSM to visit and collaborate with the rest of the authors at Ege University; COST Action 16217 (ENIUS) for designating him as a disseminator to “promote” the Action at 4th international Symposium on Nanoengineering for Mechanobiology (N4M), where some of the ideas presented in this review were discussed; and Republic of Turkey Ministry of Development [EGEMATAL;2010K120810] for financing Dr. Ece Bayir.


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© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Central Research Test and Analysis Laboratory Application and Research Center (EGE-MATAL)Ege UniversityIzmirTurkey
  2. 2.Department of BioengineeringEge UniversityIzmirTurkey
  3. 3.Department of Mechanical Engineering & AeronauticsUniversity of PatrasPatrasGreece

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