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Biophysical Reviews

, Volume 11, Issue 3, pp 277–278 | Cite as

ABA/ASB Omics 2018

  • David A. StroudEmail author
Commentary

Biophysics is the study of biological systems and processes through physics-based methods or using ideas based on physical principals (Zhou 2011). Perhaps, it is surprising to the reader that a joint meeting of the Asian Biophysics Association/Australian Society for Biophysics would contain a session dedicated to ‘omics technologies, given that the latter is commonly believed to provide researchers with a top-level view of their biological system, while biophysics approaches tend to focus on very specific molecular details. However, as we learned in the Omics session on the morning of Monday 3rd of December 2018, Omics research is highly complementary to modern biophysics, with researchers from both fields working together on projects to uncover the mechanisms driving complex biological systems.

The first session was opened by Associate Investigator Dr. Meng-Qiu Dong from the National Institute of Biological Sciences in Beijing. Chemical crosslinking and mass-spectrometry (CXMS) has...

Notes

Compliance with ethical standards

Conflict of interest

David A. Stroud declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.

References

  1. Archer SK, Shirokikh NE, Beilharz TH, Preiss T (2016) Dynamics of ribosome scanning and recycling revealed by translation complex profiling. Nature 535:570–574CrossRefGoogle Scholar
  2. Cain JA et al (2019) Proteomics reveals multiple phenotypes associated with N-linked glycosylation in campylobacter jejuni. Mol Cell Proteomics 18:715–734CrossRefGoogle Scholar
  3. Chen MZ et al (2017) A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun 8:474CrossRefGoogle Scholar
  4. Cox AG et al (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol 18:886–896CrossRefGoogle Scholar
  5. Cox AG et al (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth EMBO J 37Google Scholar
  6. Ding YH et al (2016) Increasing the depth of mass-spectrometry-based structural analysis of protein complexes through the use of multiple cross-linkers. Anal Chem 88:4461–4469CrossRefGoogle Scholar
  7. Fazakerley DJ et al (2018) Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance Elife 7Google Scholar
  8. Gong Z, Liu Z, Dong X, Ding YH, Dong MQ, Tang C (2017) Protocol for analyzing protein ensemble structures from chemical cross-links using DynaXL. Biophys Rep 3:100–108CrossRefGoogle Scholar
  9. Harding CM et al (2019) A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host. Nat Commun 10:891CrossRefGoogle Scholar
  10. Harrison PF, Pattison AD, Powell DR, Beilharz TH (2019) Topconfects: a package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list. Genome Biol 20:67CrossRefGoogle Scholar
  11. Humphrey SJ, Karayel O, James DE, Mann M (2018) High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform. Nat Protoc 13:1897–1916CrossRefGoogle Scholar
  12. Parker BL et al (2019) An integrative systems genetic analysis of mammalian lipid metabolism. Nature 567:187–193CrossRefGoogle Scholar
  13. Shirokikh NE, Archer SK, Beilharz TH, Powell D, Preiss T (2017) Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination. Nat Protoc 12:697–731CrossRefGoogle Scholar
  14. Skinnider MA, Scott NE, Prudova A, Stoynov N, Stacey RG, Gsponer J, Foster LJ (2018) An atlas of protein-protein interactions across mammalian tissues BioRxiv 351247 [Preprint] June 20, 2018 [Cited 2019 April 3].  https://doi.org/10.1101/351247
  15. Zhang X et al (2018) Carboxylate-selective chemical cross-linkers for mass spectrometric analysis of protein structures. Anal Chem 90:1195–1201CrossRefGoogle Scholar
  16. Zhou HX (2011) Q&A: what is biophysics? BMC Biol 9:13CrossRefGoogle Scholar

Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology InstituteThe University of MelbourneMelbourneAustralia

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