Biophysical Reviews

, Volume 11, Issue 2, pp 135–137 | Cite as

Recollections of 50 years of research in biophysics: a matter of hard work and luck

  • Cris dos RemediosEmail author
Letter to the Editor

This Letter is intended to complement an accompanying Letter by Amy Li who completed her PhD in my laboratory and then spent a several years doing cutting edge single-molecule research at the University of Vermont. Hers is a story of the challenges facing a young investigator in the early stages of building a research career in biophysics. She rightly voices concern over the limitation of opportunities compared to the ‘good old days’. Tenure-track positions have indeed largely vaporised. Research funding is increasingly competitive, even if early career candidates do get slightly favourable opportunities with Australia’s National Health & Medical Research funding.

My Letter speaks from the other end of a research career dating back to the 1960s when I began thinking about a research career. In those days, PhD Scholarships were few and were barely enough to live on. One needed to share accommodation with other students or have understanding parents who might tolerate supporting a son...


Compliance with ethical standards

Conflict of interest

Cris dos Remedios declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.


  1. Huxley HE (1964) The mechanism of muscle contraction. Sci Am 213:67–72Google Scholar
  2. dos Remedios CG (1969) PhD: studies on muscle contraction. The University of SydneyGoogle Scholar
  3. dos Remedios CG, Millikan RGC, Morales MF (1972) Polarization of tryptophan fluorescence from single striated muscle fibres. A molecular probe of contractile state. J Gen Physiol 59:103–120CrossRefGoogle Scholar
  4. Ostap E, Franzini-Armstrong C, Goldman YE et al (2004) Fifty important papers in the history of muscle contraction and myosin motility. J Muscle Res Cell Motil 25:475–479CrossRefGoogle Scholar
  5. dos Remedios CG, Dickens MJ (1978) Actin microcrystals and tubes formed in the presence of gadolinium ions. Nature 276:731–733CrossRefGoogle Scholar
  6. Trahair T, Yeoh T, Cartmill T (1993) Myosin light chain gene expression associated with diseased states of the human heart. J Mol Cell Cardiol 26:577–585CrossRefGoogle Scholar
  7. dos Remedios CG, Lal SP, Li A et al (2017) The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophys Rev 9:431–441. CrossRefGoogle Scholar

Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Discipline of Anatomy & Histology, Faculty of Medicine and HeathThe University of SydneySydneyAustralia

Personalised recommendations