Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective
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The Sydney Heart Bank (SHB) has contributed and continues to contribute samples of human left ventricles to our understanding of molecular mechanisms underlying heart failure (Li et al. 2013; Li and dos Remedios 2015). The great majority of the publications concern myofibrillar proteins. To date, the SHB has published about 120 research papers with about 60 collaborators around the world. About 20% of them involved genes and proteins that did not involve sarcomeric proteins.
Working with the SHB
The authors took the position that we should not expect to identify all of the causes of heart failure mechanisms, and that the best way forward would be to collaborate with the many laboratories in searching for an answer. The major obstacle to this aspiration was the need to convince these labs that your heart samples were unique in several ways. First we had to dispel the notion that our samples were degraded, or at least partially degraded due to the time between harvesting and preservation...
Compliance with ethical standards
Conflict of interest
C. G. dos Remedios declares that he has no conflicts of interest. A. Li declares that she has no conflicts of interest. S. Lal declares that he has no conflicts of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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