Foreword to ‘Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines’, a special issue in Honour of Fumio Arisaka’s 70th birthday
This issue of Biophysical Reviews, titled ‘Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines’, is a collection of articles dedicated in honour of Professor Fumio Arisaka’s 70th birthday. Initially, working in the fields of haemocyanin and actin filament assembly, Fumio went on to publish important work on the elucidation of structural and functional aspects of T4 phage biology. As his career has transitioned levels of complexity from proteins (hemocyanin) to large protein complexes (actin) to even more massive bio-nanomachinery (phage), it is fitting that the subject of this special issue is similarly reflective of his multiscale approach to structural biology. This festschrift contains articles spanning biophysical structure and function from the bio-molecular through to the bio-nanomachine level.
Professor Fumio Arisaka is one of the most well-known biophysical scientists in Japan. Holding senior offices in the Asia Pacific Protein Association, the Protein Science Society of Japan and the Biophysical Society of Japan, he has been one of the mainstays of Japanese scientific practice and international engagement for the last four decades. He has promoted scientific education (via extensive teaching, translation of foreign textbooks and writing of original scientific textbooks), championed the development and usage of biophysical methods concerned with the evaluation of structure and function of biomolecules in solution (light scattering and analytical ultracentrifugation) and made major contributions in the area of structural biology of bacterial viruses (T4 phage). Aside from his important contributions to both the structure and practice of science, he has lived a genuinely fascinating life that should be of interest to the readers of Biophysical Reviews. In this Foreword, we will try and tell some of Fumio’s scientific and personal story, with the caveat that we (as scientists) probably lack the necessary biographical talents to fully do justice to it. However, despite our literary short-comings, we think that the story of Fumio’s life and scientific achievements carry within them sufficient excitement1 to make up for our imperfect exposition.
Multiscale structural biology: Elucidation of biologically relevant structural information over a size scale ranging from the cellular to molecular and atomic levels via the combination of experiments with computer modelling and simulation.
biomolecules and biophysical principles: in which we include contributions pitched at the level of molecular characterization or modelling based on basic physical principles (Soares da Costa et al. 2018; Arai 2018a; Senda and Senda 2018; Kato et al. 2018a; Arakawa 2018; Mizohata et al. 2018; Mio and Sato 2018; North et al. 2018; Unzai 2018; Furutani 2018; Rivas and Minton 2018; Akazawa-Ogawa et al. 2018; Uchiyama et al. 2018; Nagai et al. 2018; Ando 2018; Sawitri et al. 2018; Ogawa and Hirokawa 2018; Okamoto et al. 2018; Fujiwara and Masuda 2018; Sahlan et al. 2018; Takahashi et al. 2018; Mitsutake and Takano 2018),
molecular assemblies: where we include articles examining the mechanism of, and functional effects produced by, changes in biomolecular quaternary structure (Arai 2018b; Toda et al. 2018; Yagi et al. 2018; Kato et al. 2018b; Kohda 2018; Urade et al. 2018; Sekiya et al. 2018; Sasahara 2018; Hyman and van Raaij 2018; Kuroda 2018; Nogi 2018; Goto et al. 2018; Song 2018; Yamaguchi and Kuwata 2018; Chatani and Yamamoto 2018),
bio-nanomachines: this section includes reviews describing a number of different examples of super-scale molecular assemblies with a focus on placing their behaviour at the life/machine interface (Fig. 1) (Inaba and Ueno 2018; Mima 2018; Nakagawa et al. 2018; Serwer et al. 2018; Quax and Daum 2018; Phillips-Jones and Harding 2018; Dowah and Clokie 2018; Katoh and Satoh 2018; Ekimoto and Ikeguchi 2018; Kitao and Hata 2018; Mizobata and Kawata 2018; Imada 2018; Nishikawa and Kinjo 2018; Tayo 2017).
To each of the Guest Editors, Fumio has played a different role. To DH, he was a much appreciated supervisor (2007) and continuing academic collaborator (2008-present); to JT, he was a friend and trusted academic colleague whilst working together at Tokyo Institute of Technology (1991–1998) (and continues to be an invaluable advisor regarding the theoretical and practical aspects of analytical ultracentrifugation), whilst to HN, he was a university colleague, fellow committee member and co-author of a series of textbooks. However, to all, Fumio has been a loyal friend and an extremely stimulating scientific discussion partner. It is with great pleasure and pride that we have collectively assembled this special issue in honour of Fumio’s 70th birthday. We would like to thank all contributors for the kindness and perspicacity they have displayed in meeting the special issue deadline.
Our goal in this Editorial is to describe a little of Fumio’s life story and bring his scientific approach and academic achievements to the fore. To achieve the latter, we will highlight a number of papers written at different stages of Fumio’s career. To achieve the former, we have written a brief biographical sketch of Fumio’s life both inside and outside of science. The two are intertwined in the form of this mini-scientific biography.
Fumio’s family history can be traced back to the southern part of Nagano prefecture (located in central Japan) from around the 1500s.3 In the late 1500s, the Arisaka household came into conflict with the rising power of Takeda Shingen, the Daimyo (Great Lord) of the region, and were forced further east, first into the Gunma province from which they then migrated into the Kanto area (Tokyo and its surrounds). From the early 1700s, the Arisakas can be tied to the service of the Tokugawa, the most powerful of all of Japan’s Shogunates,4 who ruled Japan from 1604 to 1868. In this power structure, Fumio’s ancestors served as mid-level retainers, known as gokenin of the bushi (Samurai) class. In this role, Fumio’s forebears regulated canal trade in the Kanto area receiving annually 30 koku (rice bags) for their services. As a retainer of the last Shogun (Tokugawa Yoshinobu), Fumio’s great grandfather left the capital to move with him to Shizuoka after his resignation in 1867. This return of political power to the Emperor was the symbolic start of the Meiji restoration period. Four years later, Fumio’s great grandfather was invited back to Tokyo to serve as an officer of the Kunai-sho (Imperial Household Ministry).
Shozo Arisaka had seven children. Among them, his three sons Yoshihiko, Hideyo and Iwao were especially close. Yoshihiko (1905–1986) was a cellist and a music critic who helped contribute to the founding of Japanese Philharmonic Orchestra in 1956.7 Hideyo (1908–1952) went on to become a well-known linguist in the field of phonology. Making important discoveries from his study of the Manyo-shu and Kojiki (two of the founding historical documents of Japan), his name is remembered in the “Arisaka-law”8 which states the strict rules of usage for primary vowels in the Japanese language (Frellesvig 2010). The third of these close-knit trio was Fumio’s Father, Iwao Arisaka (1903–1970). Iwao was a career military officer who, as a young man, studied naval engineering at the Kure Imperial Navy Shipyards at which his Father Shozo commanded. After working in the Navy for several years, he was seconded to Tohoku University as a Lieutenant Colonel, a time during which he received a formal degree in engineering whilst working together with Professors Yagi and Uda—the team widely credited with developing the first functional directive antenna (“Yagi antenna”) for radar systems (Huurdeman 2003). As a Lieutenant, Iwao was seconded to Princeton as a military attache to study American developments in their early progress into the technology of radar. Having seen the advances in radar development in the USA, he felt it essential to also develop and refine this technology for military usage in Japan. Aside from his engineering activities, Iwao saw active service in the latter half of the war. Serving on the aircraft carrier ‘Shokaku’, he was stranded at sea for nearly 2 days after his ship was sunk in 1944 by the American submarine the `USS Cavalla` during the largest ever aircraft carrier battle, known (in English) as the Battle of the Philippine Sea (Stille and Bryan 2012). Eventually rescued by the Japanese Navy, Iwao Arisaka returned to military service and finished the war at the rank of Naval Colonel.
Early childhood and schooling
Fumio Arisaka was born in April, 1948, just 3 years after the conclusion of the second-world war. Fumio’s early family life was characterized by privation, due to a combination of the general devastation heaped upon Japan’s infrastructure and economy by the ally invasion and the ‘de-imperialization’ program enacted by the occupying forces which affected Fumio’s family with particular force due to his Father’s rank as a Naval Colonel. This latter aspect led to Fumio’s family losing the inherited lands and former entitlements bestowed to them first under the Shogunate and then later Imperial rule.
When Fumio’s Father was released from the allied forces decommissioning base at Yokosuka at the conclusion of the war things looked bleak. His first wife had tragically died during the war leaving him with five children to care for. This situation was coupled with lack of employment due to an occupation force’s rule that prevented any former senior military officers from taking on a government position for a period of 3 years. In spite of this grim situation, Iwao’s luck took a turn for the better after being introduced to a young school teacher named Kotoko whom he soon married. With five children from his former marriage and two new children (Fumio being one of them) coming from his second, this union resulted in a large extended family with Fumio having three elder step brothers, two elder step sisters, and one younger brother. Despite the loss of privilege and large family to support, Fumio’s childhood was nevertheless a happy one. Fumio’s father set up a small business in electronics repairs that mostly involved repairing broken radios and (the then newly released) television set. Iwao’s business was not particularly successful but, according to Fumio, this probably led to the rare situation in which his university-level science educated Father had time to instruct his children in their tours of the items in his workshop (physics and engineering), the observation of the stars at night (astronomy) along with their daily encounters with the plants and animals in the fields (biology). Alongside his school teacher mother’s encouragement and instruction, these early lessons helped to propel Fumio’s admission into the then top high school in Yokohama, Eiko Gakuen. Administered by German Jesuit priests, whom also made up a large number of the teaching staff,9 it was here that Fumio received his first formal training in physics and mathematics.
University of Tokyo (1968–1972)
Fumio was admitted to the University of Tokyo in 1968. With an initial intention to solely study the physical sciences, Fumio’s plans were affected somewhat by student unrest (daigaku toso) and protests lead by the student activist zenkyoto and communist minsei movements (Kelman 2001). Upon attending a makeup summer class on introductory biology during this disrupted period, Fumio was both impressed and strongly influenced by his university biology lecturer, Prof. Koscak Maruyama, who taught metabolism and biological chemistry. Remembering this interest, in his final year, Fumio applied to Maruyama’s laboratory for a fourth-year project and was assigned the topic of studying the effect of actomyosin fibre adsorption on lipid bilayer membrane pressure using a Langmuir surface balance—with these studies leading to Fumio’s first publications (Maruyama et al. 1973). These studies are of particular interest when placed within context of the exciting breakthroughs in the field of actin filament protein science being made in Japan at that stage by Fumio Oosawa and colleagues (Oosawa and Kasai 1962; Oosawa and Asakura 1975).
Masters degree at Tokyo University (1972–1974)
Improved chance for mastering English
A stronger bond is formed with your supervisor at the student vs. postdoctoral level.
Friends formed during PhD remain forever.
American systems of postgraduate training involve a lot more coursework and testing that may be hard for a non-native English speaker.
Those studying outside of Japan would miss out on the special structure that Japanese society is based on. In this system, each directly senior person, the senpai, has an obligation to assist their junior colleague, the kohai.
Weighing up the pros and cons, Fumio decided to take a chance and wrote to three biophysical chemists, based in America, inquiring about the chance of their supporting his future Ph.D. candidature. Although these three scientists, Charles Tanford, Serge Timasheff and Kensal Edward van Holde are all well known today, they were less famous at that time. Of the three, Prof. van Holde was the only scientist that could guarantee significant financial support, and so at the conclusion of his Master’s Degree, Fumio set his sights on the Laboratory for Physical Biochemistry at Oregon State University.
However, prior to accepting the position, an important financial obstacle remained. Although Fumio had applied for a JSPS Scholarship support, its award was contingent upon a suitable English score. To achieve this, Fumio went back to his high school instructors at the Eiko Gakuen Jesuit School, and after a brief period, he both achieved a high score on the TOEFL test (Test of English as a Foreign Language) and passed the required interview section to receive the JSPS award. These monies paid for Fumio’s air ticket (his first time on an aeroplane) as well as funding the first year of his PhD tuition and living costs.
A PhD (not a DSc) in the USA (1974–1977)
Upon arriving in van Holde’s laboratory in September of 1974, Fumio was given a choice of projects that focussed on either the biophysics of DNA complexation in the chromosome or the biophysical characterization of hemocyanin, the giant copper-based oxygen binding protein of sea creatures such as mollusc and squid (see Kato et al. 2018a, 2018b in this issue). Fumio chose the latter because it would give him the opportunity to master the analytical ultracentrifuge, which both at that time, and continuing up to the present day, was/is the most powerful procedure for examining tertiary to quaternary transitions of macromolecules in solution. At that time, van Holde’s laboratory at Oregon State University had a couple of model E analytical ultracentrifuges and van Holde was a true master of the technique with several key aspects of the methodology still bearing his stamp (van Holde and Weischet 1978; van Holde 1985).
From the personal perspective, Fumio’s time in America was also influential as it was here that he met the person who would later become his future wife. Another Japanese postdoctoral fellow at Oregon State University, (the then) Dr. Iho Yoshiyasu, introduced Fumio to a young Japanese traveller, Miss Hiroko Kawamori, who was coming to America as a tourist friend of Iho’s wife Misuzu. In 1975, the four young Japanese went on a 2-week driving sightseeing tour in Fumio’s old Pontiac station wagon, taking in the scenery of Utah, Arizona and California. Following this trip and Hiroko’s return to Japan, the two engaged in increasingly friendly correspondence until eventually deciding upon marriage at the conclusion of Fumio’s PhD and return to Japan.
The third perspective which would prove formative in Fumio’s future life was the harsh reality of the tenuous employment situation and scant funding in science. At the end of his 1 year of JSPS funding, Fumio applied for, and received, a second year of funding from the Yoshida foundation. For his third year, Fumio received a Research Assistant position in the van Holde laboratory for which he had the duty of teaching a laboratory course. In total, the monies from JSPS, Yoshida Foundation and the Oregon State University were sufficient to keep him afloat until he successfully defended his dissertation in an open hearing in June of 1977. During these latter periods of his PhD, Fumio started to look for a position back in Japan that would enable him to marry and live with his future bride in waiting Hiroko. When such a position did not eventuate, he took the advice of a German postdoctoral fellow in the laboratory, Dr. Wolfgang Weischet, and looked further afield in Europe. This eventuated in the offer of a postdoctoral position with Prof. Jürgen Engel at the Biozentrum in Basel Switzerland.
Upon finishing PhD studies, Fumio made a lightning trip back to Japan, married Hiroko and submitted visa applications for the two of them to live and work in Switzerland. After conquering the inevitable visa problems that seem to afflict most scientists and their spouses at some stage of their lives, Fumio and Hiroko moved to Switzerland, to live and begin work at the Biozentrum.
Academic career ladder
Postdoctoral training in Switzerland (1977–1980)
It is very healthy to change fields particularly early on in one’s career.
Sometimes learning on the job provides a more focused introduction to a subject area than a more formal undergraduate preparation.
Although he very much enjoyed working with Engel, both Fumio and Hiroko desired to return to Japan and continue to grow their family.12 With two overseas stints (one for his PhD and one for his first postdoc), Fumio now started the hunt for a job back in Japan. As luck would have it at that time, the Biozentrum was hosting a talk by Prof. Shin-Ichi Ishii, an expert on the protein chemistry of proteases and lectins, who was affiliated with the Department of Pharmacy at Hokkaido University. Down with influenza, the Biozentrum host asked Fumio if he would chaperone the Japanese guest speaker during his stay. After getting to know both Fumio and of his desire to return home, Prof. Ishii promised to keep his ears open for a position. The two parted on friendly terms with Fumio thinking that Prof. Ishii might be a useful source of introduction to make his way back to Japan.
An Assistant Professorship in Hokkaido (1980–1990)
Enjoying both his young family’s quiet life in Japan’s northern island of Hokkaido and the pleasant work situation (eventually settling into a suitable balance of research and teaching), Fumio admits to a certain contentedness during his 10-year stay in Prof. Ishii’s lab. However, in the cut-throat world of academia, in which stagnation can lead to career death, it was time to make the next career jump to Associate Professor. After receiving a number of rejections on his eighth application, he achieved success, securing a position at the prestigious Tokyo Institute of Technology. After relocating his family from Hokkaido to Yokohama, the then Assist. Prof. Arisaka took on an Associate Professor position in the laboratory of Prof. Tairo Oshima.
Associate professor at the Tokyo Institute of Technology (1990–2010)
In the late 1980s, Prof. Tairo Oshima was a famous figure on the Japanese science scene. Working on the origin of life topic, Prof. Oshima had spent time at NASA investigating underwater volcanic vent deep sea life. After returning to Japan, he discovered Thermus Thermophilus, a hyperthermophile now studied and exploited all over the world (Oshima and Imahori 1974). Starting in 1990, Fumio’s appointment was decided partly on the basis of his teaching potential and partly on his future capacity for research into phage biology. With a prestigious position and a happy and healthy young family, things indeed looked very bright for Fumio.
However, in both life and research, problems can (and frequently do) arise, and it is often during the process of facing and overcoming these difficulties that we are able to measure the depth of our character. For Fumio, such unexpected challenges arose from left-field and were tripartite in nature. The first involved a sudden strict tightening of Japan’s research budget due to the collapse of the Tokyo property bubble, the timing of which was coincident with his starting at the Tokyo Institute of Technology. The squeeze on government research grants that accompanied a halving of the value of Japanese Stock market and a near collapse of the banking industry in 1991 was felt by academics throughout Japan but this was especially so for a just starting out Associate Professor. The second challenge was the retirement of Prof. Oshima which occurred five years after Fumio’s commencement. To maintain continuity of research theme, the normal reaction within Japanese research institutes to such a retirement is to promote the subordinate Associate Professor paired to the retiring Professor and rehire a new Associate Professor as the newly appointed Professor’s subordinate. However, due to continued difficulties with finances, as a cost saving measure, Fumio’s institute decided to replace the retiring Professor with another tenured Associate Professor and have the two compete against each other over a 5-year period for the vacant professorial post. Needless to say, such circumstances were tough and not optimal for fostering friendship and collegiality! The third major challenge of Fumio’s early tenured period involved the changing nature of biochemical science. Those readers old enough to remember will recall that the late 1980s and early 1990s saw the decline of traditional biochemistry and the rise of molecular biology. With the retirement of Prof. Oshima, the chief champion of Fumio’s type of biophysical research approach into phage was lost within the Department, whose collective research focus was temporarily diverted by the many new available aspects of DNA technology. For the moment, the purification and physical characterization of reassembled phage components were suddenly considered old fashioned! However, with the characteristic steadiness of character that is admired by those who know him, Fumio applied himself to overcome these obstacles and slowly but surely his research program began to blossom.
Of great help to Fumio during the make or break, Associate Professor period was the sequential recruitment of two talented Assistant Professors, Shigeki Takeda (1998–2000) and Shuji Kanamaru (2003–2014). Shigeki Takeda was previously a Masters student that Fumio had helped to train during his time as an Assistant Professor in Hokkaido. During that time, they worked on a series of studies on the structure and function of the contractile tail sheath protein of bacteriophage T4 (Takeda et al. 1990; Arisaka et al. 1990). After a period completing his DSc and working as a postdoctoral fellow at the University of Tokyo, Shigeki Takeda received an offer from Fumio of the first Assistant Professor position in his laboratory. At this time, the newly appointed Assistant Professor Takeda helped Fumio to further establish his laboratory and recruit graduate students. Aside from this, Shigeki also made a number of key scientific findings, the most important of which was the discovery of the tail tube gene of Mu phage (Takeda et al. 1998b)—the model phage system particularly famous for its role in determining the action of transposable elements (also known as jumping genes) (Shapiro 1979). After completing his training with Fumio, Shigeki Takeda was later promoted to Associate Professor at Gunma University—the same university where he is now a full Professor, running his own laboratory on the topic of phage biology (Takeda 2018).
With a recent Nature publication (Kanamaru et al. 2002) and the appointment of a new Assistant Professor (Shuji Kanamaru returned from the US), Fumio’s research program began to gather pace and riding high on the success of the high profile Nature publication from that time onwards he received a series of requests for invited review articles (Kanamaru and Arisaka 2002; Arisaka et al. 2003; Leiman et al. 2003; Rossmann et al. 2004; Kanamaru and Arisaka 2005; Arisaka 2005) and an increased demand for collaborative engagements (Suzuki et al. 2002; Miller et al. 2003; Okabe et al. 2003; Myszka et al. 2003).
Following on from the high profile structure paper, Shuji and Fumio, together in collaboration with the Rossmann and Takeda laboratories, continued to advance both the structural (Kostyuchenko et al. 2005; Rossmann et al. 2007; Akhter et al. 2007; Kanamaru and Arisaka 2007; Nemoto et al. 2008) and functional (Zhao et al. 2003; Takeda et al. 2004; Kanamaru et al. 2005; Kumar-Sarkar et al. 2006; Koshiyama et al. 2009) understanding of phage biology to such an extent that the phage structural components began being seriously discussed in terms of bio-nanomachinery (Rossmann et al. 2007). During this time, a number of excellent D.Sc. students including Takuro Matsui, Said Ali, Lily Zhao, Tahmina Akther, Mai Nemoto, Moh Lan Yap, Takafumi Iura and Kazuya Uchida along with many Masters students were, together with Shuji Kanamaru, the driving force behind the discoveries made in Fumio’s laboratory. Two more important events happened during this time—the first being the recruitment of Ms. Moh Lan Yap, an exceptionally talented DSc student from Malaysia (who would later lead the next charge of phage structural biology from Fumio’s laboratory) and the second being Fumio’s promotion to full Professor.
Professor at the Tokyo Institute of Technology (2010–2015)
In the late 2000s, phage biology enjoyed a resurgence in popularity—a situation mostly due to the structural biology efforts championed by Fumio Arisaka and Michael Rossmann in the late 1990s and early 2000s. This newfound appreciation of the research area, together with a loosening of the funding spigots that always accompanies the publication of high profile/high impact papers, meant that Fumio’s research was now (once again) considered important and this re-evaluation catalyzed his promotion to a full Professorship in the Department of Life Science at the Tokyo Institute of Technology. Although providing a number of advantages, the promotion did not affect Fumio as much as it might have a much younger scientist. Fumio was already the leader of his field in Japan and one of the elite researchers in phage biology worldwide (as evidenced by a number of contributions to this special issue from office holders of the International Society for Phage Biology (Quax and Daum 2018; Hyman and van Raaij 2018; Dowah and Clokie 2018; Serwer et al. 2018)). Similarly, he was at the top of the tree with regard to expertise in biophysical characterization as could be easily shown by the long line of researchers within Japan wanting to collaborate with him.
During this latter period, other students and postdoctoral fellows associated with Fumio’s research area made significant discoveries in their particular projects. Within the phage-related area work on bacterial homologs of phage proteins (Uchida et al. 2014), mechanistic action of the gp5 trimer in the cell puncturing device (Nishima et al. 2011), and determination of the molecular architecture of the T4 phage neck region (Fokine et al. 2013) (all reviewed in Arisaka and Kanamaru 2013). Further to this, being a Professor did not slow down Fumio’s own experimental output, with his engagement in a range of collaborative projects on topics as diverse as receptor biology (Mio et al. 2010), assembly of nanotechnology components (Yokoi et al. 2010; Inaba et al. 2012; Sanghamitra et al. 2014), hemoglobin allostery (Arisaka et al. 2011), crop protein analysis (Wadahama et al. 2012; Sato et al. 2015; Yamniuk et al. 2015), autophagy (Araki et al. 2013), amyloid analysis (Zhao et al. 2016; Hall et al. 2016), biopharmaceutical development (Iwura et al. 2014a, 2014b), AUC methodological development (Zhao et al. 2015) and thermostable enzymes (Tamakoshi et al. 2011; Chen et al. 2011; Ozawa et al. 2012) among many others (Huq et al. 2010; Yamasaki et al. 2010; Kanazawa et al. 2010; Sawada et al. 2011; Akita et al. 2012; Nomura et al. 2012; Ishii et al. 2012; Nozawa et al. 2013; Seio et al. 2013; Takei et al. 2014; Kumazaki et al. 2014; Owa et al. 2014; Iwura et al. 2014a, 2014b; Arai et al. 2015; Kurasawa et al. 2015).
After retirement (2015-present)
After finishing work at the mandatory age of 65, it is common for Japanese Professors at elite public institutions to take a 5-year position at a private university where they may teach a limited number of courses and engage in research at a slightly more relaxed pace. Such a situation was important for both Fumio personally and also for his network of collaborators who depended upon him for help with a bevy of biophysical measurements. After finishing at the Tokyo Institute of Technology, Fumio took on such a retirement position at Nihon Daigaku (literally the University of Japan)—a traditional university that, in addition to the physical sciences, places a great focus on the teaching and research of Japanese culture and history. It is here that Fumio presently works in the laboratory of Prof. Kenji Ueda (Life Science Center of the School of Bioresource Science) dividing his time between teaching basic science glasses to undergraduates and engaging in collaborative experiments with colleagues throughout Japan on a range of protein science topics (Nishikawa et al. 2016; Saotome et al. 2016; Tsutsui et al. 2016; Arisaka et al. 2016).
Scientific process—societies and service
Life outside of science—hobbies, community
Outside of science, Fumio is a committed husband to his wife Hiroko and devoted father and grandfather to his four sons and two granddaughters. A semi-professional flutist Fumio practices daily both modern and traditional forms. Although his audience is often only made up of late working graduate students and research fellows, Fumio has previously performed at nearby day care centres for the elderly along with exhibitions at hospitals for the sick. This love of music is also manifest in his membership and participation in a local Kamakura choir group as well as his performance in a Gregorian chanting group. The story would not be complete without noting Fumio’s commitment to his Catholic faith—the roots of which can be traced back to his Jesuit based education during his high school days. Although deeply private in his devotion, various aspects of Fumio’s life as a practicing Catholic can be seen in his volunteer service to the various community programs run through his church.
Whilst some scientists come onto the scene like a supernova, others burn at a more even rate during their careers, often providing more warmth and illumination over a longer time. Due to his unassuming and self-deprecating nature, Professor Fumio Arisaka can, in a crowd of more flamboyant colleagues, be easily pushed from the front of the stage. Never exploitative of junior colleagues, always happy to personally put effort into a collaboration and the least likely person to ever fight over an authorship position some might say that the basic kind and generous personality type exhibited by Prof. Fumio Arisaka was perhaps not optimized for success in today’s community of professional scientists—in which a hard edge can get you a long way irrespective of knowledge or talent. Yet, despite this, Fumio Arisaka has successfully established an extremely rich and scientifically beneficial career in which his own thoughts and toil are on display in each and every publication. His consistently focussed long-time work in the field of phage biology has advanced our understanding to the point today that the DNA injection device of the T4 phage is being used as the basis for novel bio-nanomachines (e.g. Rossmann et al. 2004; Ueno et al. 2006; Yokoi et al. 2010; Yokoi et al. 2011; Sanghamitra et al. 2014; Inaba and Ueno 2018). On the human side, his career has touched a large number of scientists. Through a combination of his innate kindness and humbleness coupled with an underlying strength and determination, he has helped to make those around him both better scientists and better people.
Approaching the finishing line of an academic career, it is a victory to be able to receive the admiration and respect of colleagues who genuinely value both your human and scientific qualities. It is with this closing remark that we three, on behalf of all the contributors to this special issue,21 collectively wish Professor Fumio Arisaka all the best on the occasion of his 70th birthday and express the fact that we very much look forward to his further counsel and scientific contributions over the coming years.
Particularly for younger scientists at the beginning of their career journey.
Also included in this ‘Letters to the Editor’ front-section is a scientific letter relating to the topic in fluorescence resonance energy transfer (FRET) analysis [Yamaguchi et al 2018].
It is perhaps from this area that the Arisaka name is derived for which the Chinese kanji characters literally translate as ari ‘exist’ and saka ‘slope’.
In 1192, Minamoto Yoritomo of Kamakura (Kanto region) obtained the highest political power (Shogun) from the Emperor who resided in Kyoto. This situation lasted until 1333 when the Shogunate (or Bakufu) moved to the Kansai (Osaka/Kobe) area once again. In 1603 Tokugawa Ieyasu moved the Bakefu to Edo (Tokyo). The present Emperor’s palace in Tokyo was inherited from the Tokugawa family and was originally called Edo Castle.
Indeed Shozo was awarded the Gakushiin Onshi sho (Japan Academy Prize) based on his Heiki-ko - a three volume series on the history of armaments (Arisaka 1936).
As an interesting footnote Shozo Arisaka’s co-discovery of this pottery with Professor Shogoro Tsuboi, then Chair of Archaeology at Tokyo University, was revealed to Fumio by Tsuboi’s grandson, when he was teaching Fumio X-ray crystallography during his undergraduate degree at Tokyo University 80 years later.
Fumio’s love of music may perhaps come from the influence of his uncle Yoshihiko.
Indeed Hideyo was also awarded the Gakushiin Onshi sho (1952, Japan Academy Prize) based on his studies on “The history of Japanese Phonology”.
In later years Fumio’s Father Iwao was also recruited as a teacher of physical sciences at the Eiko Gakuen School.
After Fumio’s undergraduate degree Prof. Koscak Maruyama left the University of Tokyo to take on a position at Kyoto University which lead to Fumio entering into the laboratory of the more senior Professor Haruhiko Noda.
In which Fumio was amazed that a small drop of bacteriophage could kill all cultured E. coli cells in just 20 min.
For now, there were three Arisaka’s with Fumio and Hiroko’s first son Michio being born in Switzerland.
Prof. Ishii’s interest in phage was spurred by his discovery that the R-type pyocins of Pseudomonas Aureginosa bore close resemblance to the T4 phage tail.
Of which all three of this Editorial’s authors can attest. The title of Assistant Professor in Japanese is jokyo.
Fumio and Hiroko’s new sons were Isao Arisaka, Tetsuo Arisaka and Akio Arisaka.
In this regard, the acquisition of a new Beckman XLA analytical ultracentrifuge by Fumio and the Tokyo Institute of Technology made the institute the hub for ultracentrifugation experiments in Japan.
Even at that time, the ‘publish or perish’ paradigm was the harsh reality of life for scientific researchers.
‘Standard Seikagaku’ has gone through three editions and numerous re-printings over the course of 21 years (1996–2015) with a fourth edition recently requested by the publisher which was published as a new textbook ‘Yoku Wakaru Standard Seikagaku’ in 2016. In addition to ‘Standard Seikagaku’, ‘Introduction to Protein Science’ and ‘Butsuri Seikagaku’, Fumio has written or coauthored a further four textbooks ‘Tanpakushitsu no Jikoshuugou’ (Protein Self-Association), ‘Tanpakushitsu Kogakuno Kiso’ (Protein Engineering Basics), ‘Tanpakushitsu no Katachi to Bussei’ (Protein Shape and Properties – written together with HN, one of the three editors of this special issue) and an edited book on Analytical Ultracentrifugation written with two of the contributors to this special issue Susumu Uchiyama and Satoru Unzai.
Kensal Edward van Holde was Fumio’s PhD supervisor.
Collaborative work performed between the Rossmann and Arisaka laboratories has continued right up until the present day. With over thirteen jointly co-authored papers this connection is regarded by Fumio as one of the key positive engagements of his working life. In private conversation Fumio has remarked that the selection of a good collaborator has as much to do with temperament and character as scientific excellence and that in Michael Rossmann he found a wellspring of both.
Along with the many more who due to competing time restraints could not make the deadline for this issue.
The information in this foreword came from conversations enjoyed over a period of long friendship between the three authors and FA along with 2 days of focussed interview between DH and FA during a rainy period in Kawasaki Tokyo in the late August of 2017. The three Editors would like to thank Prof. Cris dos Remedios for his efforts in enabling this Festschrift to be part of the 2018 Biophysical Reviews issues. DH acknowledges the financial support in the form of an ANU Senior Research Fellowship and the Osaka University Associate Professor cross-appointment scheme. DH and JT would like to jointly acknowledge Osaka University for funds directly supporting the Laboratory of Multiscale Structural Biology at the Institute for Protein Research. HN gratefully acknowledges funding support from the Protein Data Base of Japan (PDBj).
Compliance with ethical standards
Conflict of interest
Damien Hall declares that he has no conflicts of interest. Junichi Takagi declares that he has no conflicts of interest. Haruki Nakamura declares that he has no conflicts of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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