Biophysical Reviews

, Volume 9, Issue 6, pp 931–940 | Cite as

Stimuli-responsive nanocarriers for intracellular delivery

  • Lemmuel L. TayoEmail author


The emergence of different nanoparticles (NPs) has made a significant revolution in the field of medicine. Different NPs in the form of metallic NPs, dendrimers, polymeric NPs, carbon quantum dots and liposomes have been functionalized and used as platforms for intracellular delivery of biomolecules, drugs, imaging agents and nucleic acids. These NPs are designed to improve the pharmacokinetic properties of the drug, improve their bioavailability and successfully surpass physiological or pathological obstacles in the biological system so that therapeutic efficacy is achieved. In this review I present some of the current approaches used in intracellular delivery systems, with a focus on various stimuli-responsive nanocarriers, including cell-penetrating peptides, to highlight their various biomedical applications.


Nanocarrier Drug delivery Stimuli-responsive Intelligent materials Nanomedicine 



I would like to congratulate Prof. Fumio Arisaka for his long scientific career and significant contribution to the field of life sciences. I wish him a blissful 70th birthday and more fruitful years to come. I also acknowledge the organizers of this special edition of Biophysical Reviews.

Compliance with ethical standards

Conflict of interest

Lemmuel L. Tayo declares that he has no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.


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© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.School of Chemical, Biological, and Materials Engineering and SciencesMapúa UniversityIntramuros ManilaPhilippines

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