Stimuli-responsive nanocarriers for intracellular delivery
- 298 Downloads
The emergence of different nanoparticles (NPs) has made a significant revolution in the field of medicine. Different NPs in the form of metallic NPs, dendrimers, polymeric NPs, carbon quantum dots and liposomes have been functionalized and used as platforms for intracellular delivery of biomolecules, drugs, imaging agents and nucleic acids. These NPs are designed to improve the pharmacokinetic properties of the drug, improve their bioavailability and successfully surpass physiological or pathological obstacles in the biological system so that therapeutic efficacy is achieved. In this review I present some of the current approaches used in intracellular delivery systems, with a focus on various stimuli-responsive nanocarriers, including cell-penetrating peptides, to highlight their various biomedical applications.
KeywordsNanocarrier Drug delivery Stimuli-responsive Intelligent materials Nanomedicine
I would like to congratulate Prof. Fumio Arisaka for his long scientific career and significant contribution to the field of life sciences. I wish him a blissful 70th birthday and more fruitful years to come. I also acknowledge the organizers of this special edition of Biophysical Reviews.
Compliance with ethical standards
Conflict of interest
Lemmuel L. Tayo declares that he has no conflicts of interest.
This article does not contain any studies with human participants or animals performed by the author.
- Babin J, Pelletier M, Lepage M, Allard J-F, Morris D, Zhao Y (2009) A new two-photon sensitive block copolymer nanocarrier. Angew Chem Int Ed 48:3329–3332Google Scholar
- Baghbani F, Chegeni M, Moztarzadeh F, Hadian-Ghazvini S, Raz M (2017a) Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: curcumin. Mater Sci Eng C 74:186–193Google Scholar
- Baghbani F, Chegeni M, Moztarzadeh F, Mohandesi JA, Mokhtari-Dizaji M (2017b) Ultrasonic nanotherapy of breast cancer using novel ultrasound-responsive alginate-shelled perfluorohexane nanodroplets: in vitro and in vivo evaluation. Mater Sci Eng C 77:698–707Google Scholar
- Chan DCF, Kirpotin DB, Bunn PA (1993) Synthesis and evaluation of colloidal magnetic iron-oxides for the site-specific radiofrequency induced hyperthermia of cancer. J Magn Magn Mater 122:374–378Google Scholar
- Ding C, Li Z (2017) A review of drug release mechanisms from nanocarrier systems. Mater Sci Eng C 76:1440–1453Google Scholar
- Dowaidara M, Abdelhamid HN, Hällbrink M, Zou X, Langel U (2017) Graphene oxide nanosheets in complex with cell penetrating peptides for oligonucleotides delivery. BBA Gen Subjects 1861:2334–2341Google Scholar
- Dumville JC, O'Meara S, Deshpande S, Speak K (2011) Hydrogel dressings for healing diabetic foot ulcers. Cochrane Database Syst Rev 9:CD009101Google Scholar
- Frimpong RA, Hilt JZ (2010) Magnetic nanoparticles in biomedicine: synthesis, functionalization and applications. Nanomedicine (London) 5:1401–1414Google Scholar
- Han G, Ghosh P, De M, Rotello VM (2007) Drug and gene delivery using gold nanoparticles. NanoBiotechnology 3:40–45Google Scholar
- Jeong JH, Kim SW, Park TG (2007) Molecular design of functional polymers for gene therapy. Prog Polym Sci 32:1239–1274Google Scholar
- Jia YP, Ma BY, Wei XW, Qian ZY (2017) The in vitro and in vivo toxicity of gold nanoparticles. Chin Chem Lett 28:691–702Google Scholar
- Joshi S, Cooke JRN, Chan DKW, Ellis JA, Hossain SS, Singh-Moon RP, Wang M, Bigio IJ, Bruce JN, Straubinger RM (2017) Liposome size and charge optimization for intraarterial delivery to gliomas. Drug Deliv Transl Res 3:225–233Google Scholar
- Kooiman K, Vos HJ, Versluis M, de Jong N (2014) Acoustic behavior of microbubbles and implications for drug delivery. Adv Drug Deliv Rev 72C:28–48Google Scholar
- Kumar B, Jalodia K, Kumar P, Gautam HK (2017) Recent advances in nanoparticle-mediated drug delivery. J Drug Delivery Sci Technol 41:260–268Google Scholar
- Kunath K, von Harpe A, Fischer D, Peterson H, Bickel U, Voigt K, Kissel T (2003) Low molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high molecular weight polyethylenimine. J Control Release 89:113–125PubMedGoogle Scholar
- Lehner R, Wang X, Marsch S, Hunziker P (2013) Intelligent nanomaterials for medicine: carrier platforms and targeting strategies in the context of clinical application. Nanomed Nanotech Biol Med 9:742–757Google Scholar
- Liu M, Du H, Zhang W, Zhai G (2017) Internal stimuli-responsive nanocarriers for drug delivery: design strategies and applications. Mater Sci Eng C 71:1267–1280Google Scholar
- Marturano V, Cerruti P, Carfagna C, Giamberini M, Tylkowski B, Ambrogi V (2015) Photo-responsive polymer nanocapsules. Polymer 70:222–230Google Scholar
- Saravanakumar G, Kim WJ (2014) Stimuli-responsive polymeric nanocarriers as promising drug and gene delivery systems. In: Prokop A, Iwasaki Y, Harada A (eds) Intracellular delivery II. Springer International Publishing AG, Cham, pp 55–91Google Scholar
- Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S et al (1985) A new class of polymers: starburst-dendritic macromolecules. Polym J 17:117–132Google Scholar
- Wang P, Yin T, Li J, Zheng B, Wang X, Wang Y, Zheng J, Zheng R (2016) Ultrasound-responsive microbubbles for sonography-guided siRNA delivery. Nanomed Nanotech Biol Med 12:1139–1149Google Scholar
- Wei H, Zhuo R-X, Zhang X-Z (2013) Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Prog Polym Sci 38:503–535Google Scholar
- Zhang W, Shi L, Wu K, An Y (2005) Thermoresponsive micellization of poly(ethylene glycol)-bpoly(N-isopropylacrylamide) in water. Macromolecules 38:5743–5747Google Scholar
- Zhao Y (2012) Light-responsive block copolymer micelles. Macromolecules 45:3647–3657Google Scholar