Therapeutic Effects of Multimodal Biophysical Stimulation on Muscle Atrophy in a Mouse Model

  • Seohyun Kim
  • Donghyun Hwang
  • Hana Lee
  • Donghyun Seo
  • Seungkwan Cho
  • Byungjo Jung
  • Jongbum Seo
  • Han Sung KimEmail author
Regular Paper


Muscle atrophy is defined as the decrease in the size and number of muscle fibers, and is associated with injury to muscle structures. Recently, biophysical therapies using laser, ultrasound, and vibration has been widely used to improve muscle atrophy. However, although the effects of these stimuli seem to be similar, the mechanisms by which they stimulate biological tissue may be different. From this point of view, we expected that it would be possible to produce synergetic effects through combining these three different types of biophysical stimuli on biological tissues, based on the therapeutic benefit of each stimulus. For this, 35 males, 12-week old, C57BL/6 mice (21 ± 1.2 g), were randomly assigned to five groups: a) a sciatic nerve neurectomized “control” group (C, n = 7), b) a MILNS (Minimally Invasive Laser Needle System) therapy after sciatic nerve neurectomized group (L, n = 7), c) a LIPUS (Low-Intensity Pulsed Ultrasound) therapy after sciatic nerve neurectomized group (U, n = 7), e) a PVS (Partial Vibration Stimulation) therapy after sciatic nerve neurectomized group (V, n = 7), and e) a multimodal biophysical stimulation after sciatic nerve neurectomized group (MS, n = 7).


Muscle atrophy Sciatic nerve neurectomy Multimodal biophysical stimulation Vibration Laser Ultrasound 


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Copyright information

© Korean Society for Precision Engineering and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical Engineering and Research Institute for Medical Instruments & Rehabilitation EngineeringYonsei UniversityGangwon-doRepublic of Korea
  2. 2.Cell BiotechGyeonggi-doRepublic of Korea
  3. 3.CELLOGINGangwon-doRepublic of Korea

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