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Effects of a Titanium Dioxide Thin Film for Improving the Biocompatibility of Diamond-Like Coated Coronary Stents

  • Jae Won Shim
  • In-Ho Bae
  • Myung Ho JeongEmail author
  • Dae Sung Park
  • Kyung-Seob Lim
  • Jae Un Kim
  • Mun-Ki Kim
  • Jung Ha Kim
  • Ju Han Kim
  • Doo Sun Sim
Article
  • 8 Downloads

Abstract

This study was performed to evaluate the effects of a diamond-like carbon (DLC) layer on the biological properties of a pre-treated titanium dioxide (TiO2) coronary stent surface. TiO2 and DLC were coated onto a cobalt-chromium stent surface in consecutive order using the plasma-enhanced chemical vapor deposition method (TiO2/DLC). To investigate the effect of TiO2, a group treated only with DLC was also prepared as a control. The surface characteristics were investigated by SEM, ESCA, AFM, and contact angle analyses. To estimate the effect of surface modification on biological response, endothelial cell migration was carried out. As a result, cracking of the coating layer on the strut curved portion in the DLC group was restored in the TiO2/DLC group. ESCA result showed that the peaks sp2 and sp3 were slightly shifted and higher in the TiO2/DLC group. The surface roughness average was highly increased in the TiO2/DLC group (Ra; 18.033) compared to the BMS (Ra; 9.258) and DLC groups (Ra; 10.144). By the increment of Ra, the surface property became hydrophilic in the TiO2/DLC group (39.8° ± 5.88°) compared to the non-treated (72.7° ± 2.24°) and DLC (78.6° ± 2.24°) groups. Endothelial cell migration was significantly increased in the TiO2/DLC group (68.9 ± 13.52%) compared to the non-treated (5.4 ± 3.14%) and DLC groups (22.3 ± 8.22%). Therefore, the improvement of surface properties and endothelial cell migration in the TiO2/DLC group could improve the physiological response in the human body.

Graphic Abstract

Keywords

Coronary stent Diamond-like carbon Titanium dioxide Surface modification Endothelialization 

Notes

Acknowledgements

This study was supported by a Grant from the Korean Health Technology R&D Project (HI13C1527) and the Korea Health Industry Development Institute (KHIDI) (HI17C0471), funded by the Ministry of Health and Welfare, Republic of Korea.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Korean Institute of Metals and Materials 2019

Authors and Affiliations

  • Jae Won Shim
    • 1
    • 2
    • 5
  • In-Ho Bae
    • 1
    • 2
  • Myung Ho Jeong
    • 1
    • 2
    • 3
    • 5
    Email author
  • Dae Sung Park
    • 1
    • 2
  • Kyung-Seob Lim
    • 4
  • Jae Un Kim
    • 1
    • 2
  • Mun-Ki Kim
    • 1
  • Jung Ha Kim
    • 1
  • Ju Han Kim
    • 2
    • 3
  • Doo Sun Sim
    • 1
    • 2
    • 3
  1. 1.The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated By Korea Ministry of Health and WelfareGwangjuRepublic of Korea
  2. 2.Korea Cardiovascular Stent Research InstituteJangsungRepublic of Korea
  3. 3.Department of CardiologyChonnam National University HospitalGwangjuRepublic of Korea
  4. 4.National Primate Research Center and Futuristic Animal Resource and Research CenterKorea Research Institute of Bioscience and BiotechnologyCheongjuRepublic of Korea
  5. 5.Molecular Medicine, BK21 PlusChonnam National University Graduate SchoolGwangjuRepublic of Korea

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