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Identifying Antioxidant Proteins by Using Optimal Dipeptide Compositions

  • Pengmian Feng
  • Wei ChenEmail author
  • Hao LinEmail author
Original Research Article

Abstract

Antioxidant proteins are a kind of molecules that can terminate cellular and DNA damages caused by free radical intermediates. The use of antioxidant proteins for prevention of diseases has been intensively studied in recent years. Thus, accurate identification of antioxidant proteins is essential for understanding their roles in pharmacology. In this study, a support vector machine-based predictor called AodPred was developed for identifying antioxidant proteins. In this predictor, the sequence was formulated by using the optimal 3-gap dipeptides obtained by using feature selection method. It was observed by jackknife cross-validation test that AodPred can achieve an overall accuracy of 74.79 % in identifying antioxidant proteins. As a user-friendly tool, AodPred is freely accessible at http://lin.uestc.edu.cn/server/AntioxiPred. To maximize the convenience of the vast majority of experimental scientists, a step-by-step guide is provided on how to use the web server to obtain the desired results.

Keywords

Antioxidant protein AodPred g-gap dipeptides composition Support vector machine 

Notes

Acknowledgments

This work was supported by National Nature Scientific Foundation of China (Nos. 61100092 and 61202256), Nature Scientific Foundation of Hebei Province (No. C2013209105), and Foundation of Science and Technology Department of Hebei Province (No. 132777133).

Compliance with ethical standards

Conflict of interest

The authors have declared that no competing interests exist.

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Copyright information

© International Association of Scientists in the Interdisciplinary Areas and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.School of Public HealthNorth China University of Science and TechnologyTangshanChina
  2. 2.Department of Physics, School of Sciences, Center for Genomics and Computational BiologyNorth China University of Science and TechnologyTangshanChina
  3. 3.Key Laboratory for Neuro Information of Ministry of Education, Center of Bioinformatics, School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina

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