International Journal of Behavioral Medicine

, Volume 25, Issue 5, pp 517–525 | Cite as

Sleep Quality in Ulcerative Colitis: Associations with Inflammation, Psychological Distress, and Quality of Life

  • Megan M. HoodEmail author
  • Rebecca Wilson
  • Annika Gorenz
  • Sharon Jedel
  • Shohreh Raeisi
  • Stevan Hobfoll
  • Ali Keshavarzian



Treatment of ulcerative colitis (UC), given its chronicity and its associated disruptive and often distressing symptoms, is increasingly focusing on maximizing patient quality of life. Poorer quality of life has been found among patients with poor sleep quality, which is much more common in patients with UC than in the general population and may be associated with inflammation and psychological distress.


Forty-seven patients with UC (n = 11 flaring) completed measures of sleep quality, depression, state anxiety, gastrointestinal-related anxiety, perceived stress, and quality of life. Measures of inflammation were also obtained.


Patients endorsed high rates of poor sleep quality, which was highly correlated with depression and poorer inflammatory bowel disease-related quality of life, but was generally not related to other areas of psychological functioning or inflammation. Sleep quality was significantly independently associated with depression and female gender.


Poor sleep quality is prevalent in patients with UC and is strongly related to depression, suggesting that sleep and mood are important areas to assess in patients with UC in order to inform tailored treatment to improve quality of life.


Inflammatory bowel disease Quality of life Sleep quality Ulcerative colitis Depression Distressing symptoms 


Funding Information

This work was supported by the National Center for Complementary and Integrative Health at the National Institutes of Health (grant number 5R01AT007143-05).

Compliance with Ethical Standards

This study was approved by the Institutional Review Board and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all individuals included in the study.

Conflict of Interest

The authors declare that there is no conflict of interest.


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Copyright information

© International Society of Behavioral Medicine 2018

Authors and Affiliations

  1. 1.Rush University Medical CenterChicagoUSA

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