Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

  • Isabel Cuéllar-Flores
  • Talía Saínz
  • Carlos Velo
  • María Isabel González-ToméEmail author
  • Cristina García-Navarro
  • Carolina Fernández-Mcphee
  • Sara Guillén
  • José Tomás Ramos
  • Pilar Miralles
  • Rafael Rubio
  • José Ignacio Bernardino
  • Luis Prieto
  • Pablo Rojo
  • Santiago Jiménez de Ory
  • Maria Luisa Navarro
  • CoRiSpe (FARO and NeuroCoRISpeS projects, RITIP -Traslational Research Network in Pediatric Infectious Diseases)
Original Article



Studies investigating health-related quality of life (HRQoL) in youth with perinatally acquired HIV (PHIV+) are scarce. This study aimed to compare HRQoL of PHIV+ to sociodemographic-matched youth not living with HIV (HIV−), Spanish general youth population, and to explore associations between sociodemographic variables, drug consumption, and HRQoL.


PHIV+ youth were randomly selected from CoRISpe database (Cohort of the Spanish Pediatric HIV Network). HRQoL was evaluated by SF-12v2.


Thirty-nine PHIV+ youth (mean age: 23.36 years, SD = 3.83) and thirty-nine HIV− youth (mean age: 22.97 years, SD = 3.80) participated in this study. PHIV+ obtained lower scores in SF-12 physical health subscale (PCS) than HIV− (P = 0.001) and Spanish general youth population (P = 0.006). PHIV+  had lower scores on the mental health subscale (MCS) than the Spanish general youth population (P < 0.001). PHIV+  who were at school obtained better scores than those were not at school. PHIV+  youth who had used cocaine and cannabis had lower scores in MCS (P = 0.002).


There is a need for HRQoL management in the associated medical follow-up.


Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth 


Author contributions

MGT, TS, and MLN conceived of the presented idea. CN, ICF, and CV performed the measurements. ICF and CV developed the theoretical formalism, performed the analytic calculations, and performed the numerical simulations. They also performed the analysis, drafted the manuscript, and designed the figures. All authors discussed the results and commented on the manuscript and contributed to the final version of the manuscript.


This work was supported by Instituto de Salud Carlos III [FIS 15/00694] which is co-funded by Fondo Europeo de Desarrollo Regional (FEDER): Una manera de hacer Europa;). TS has been funded by a 2014 Research Fellowship Award from the European Society of Pediatric Infectious Diseases (ESPID) and the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos IIII, Contratos Juan Rodés, JR16/00021) and Feder-FFE. CV was funded by Comunidad de Madrid and fondos FEDER (Ayudas para la contratación de ayudantes de Investigación y técnicos de laboratorio/Orden 2524/2016, de 1 de agosto, BOCM núm. 188, de 8 de agosto de 2016). CoRISpeS-Cohorte de Madrid (Pediatric HIV Infection National Cohort) is included in the AIDS Research Network (RED-RIS) since 2008, and funded by Instituto de Salud Carlos III (RD16/0025/0019), ISCIII-Subdirección General de Evaluación and el Fondo Europeo de Desarrollo Regional (FEDER) [RIS_EPICLIN_11_2019, RIS-EPICLIN-12/2012 and RIS-EPICLIN-06/2013).

Compliance with ethical standards

Ethical approval

The study protocol and questionnaires were approved by the Ethic Committee of the participating hospitals.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2019

Authors and Affiliations

  • Isabel Cuéllar-Flores
    • 1
  • Talía Saínz
    • 2
    • 3
  • Carlos Velo
    • 4
  • María Isabel González-Tomé
    • 4
    Email author
  • Cristina García-Navarro
    • 4
  • Carolina Fernández-Mcphee
    • 5
  • Sara Guillén
    • 6
  • José Tomás Ramos
    • 1
  • Pilar Miralles
    • 7
  • Rafael Rubio
    • 8
  • José Ignacio Bernardino
    • 9
  • Luis Prieto
    • 4
  • Pablo Rojo
    • 4
  • Santiago Jiménez de Ory
    • 10
  • Maria Luisa Navarro
    • 5
    • 10
    • 11
    • 12
  • CoRiSpe (FARO and NeuroCoRISpeS projects, RITIP -Traslational Research Network in Pediatric Infectious Diseases)
  1. 1.Pediatric DepartmentHospital Clínico San CarlosMadridSpain
  2. 2.Infectious Diseases Service, Paed DepartmentHospital La PazMadridSpain
  3. 3.La Paz Research Institute (IdiPAZ)MadridSpain
  4. 4.Infectious Diseases Service, Paed DepartmentHospital 12 de OctubreMadridSpain
  5. 5.Infectious Diseases Service, Paed DepartmentH. Gregorio MarañónMadridSpain
  6. 6.Paed DepartmentHospital de GetafeMadridSpain
  7. 7.Infectious Diseases ServiceH. Gregorio MarañónMadridSpain
  8. 8.HIV ServiceHospital 12 de OctubreMadridSpain
  9. 9.Infectious Diseases ServiceHospital La PazMadridSpain
  10. 10.Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM)MadridSpain
  11. 11.Universidad Complutense de MadridMadridSpain
  12. 12.Translational Research Network in Pediatric Infectious Diseases (RITIP)MadridSpain

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