Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV
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Studies investigating health-related quality of life (HRQoL) in youth with perinatally acquired HIV (PHIV+) are scarce. This study aimed to compare HRQoL of PHIV+ to sociodemographic-matched youth not living with HIV (HIV−), Spanish general youth population, and to explore associations between sociodemographic variables, drug consumption, and HRQoL.
PHIV+ youth were randomly selected from CoRISpe database (Cohort of the Spanish Pediatric HIV Network). HRQoL was evaluated by SF-12v2.
Thirty-nine PHIV+ youth (mean age: 23.36 years, SD = 3.83) and thirty-nine HIV− youth (mean age: 22.97 years, SD = 3.80) participated in this study. PHIV+ obtained lower scores in SF-12 physical health subscale (PCS) than HIV− (P = 0.001) and Spanish general youth population (P = 0.006). PHIV+ had lower scores on the mental health subscale (MCS) than the Spanish general youth population (P < 0.001). PHIV+ who were at school obtained better scores than those were not at school. PHIV+ youth who had used cocaine and cannabis had lower scores in MCS (P = 0.002).
There is a need for HRQoL management in the associated medical follow-up.
KeywordsDrug consumption Health-related quality of life Mental health Perinatally acquired HIV youth
MGT, TS, and MLN conceived of the presented idea. CN, ICF, and CV performed the measurements. ICF and CV developed the theoretical formalism, performed the analytic calculations, and performed the numerical simulations. They also performed the analysis, drafted the manuscript, and designed the figures. All authors discussed the results and commented on the manuscript and contributed to the final version of the manuscript.
This work was supported by Instituto de Salud Carlos III [FIS 15/00694] which is co-funded by Fondo Europeo de Desarrollo Regional (FEDER): Una manera de hacer Europa;). TS has been funded by a 2014 Research Fellowship Award from the European Society of Pediatric Infectious Diseases (ESPID) and the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos IIII, Contratos Juan Rodés, JR16/00021) and Feder-FFE. CV was funded by Comunidad de Madrid and fondos FEDER (Ayudas para la contratación de ayudantes de Investigación y técnicos de laboratorio/Orden 2524/2016, de 1 de agosto, BOCM núm. 188, de 8 de agosto de 2016). CoRISpeS-Cohorte de Madrid (Pediatric HIV Infection National Cohort) is included in the AIDS Research Network (RED-RIS) since 2008, and funded by Instituto de Salud Carlos III (RD16/0025/0019), ISCIII-Subdirección General de Evaluación and el Fondo Europeo de Desarrollo Regional (FEDER) [RIS_EPICLIN_11_2019, RIS-EPICLIN-12/2012 and RIS-EPICLIN-06/2013).
Compliance with ethical standards
The study protocol and questionnaires were approved by the Ethic Committee of the participating hospitals.
Conflict of interest
No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.
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