Management of persistent pulmonary hypertension in newborns with ECMO support: a single center's experience

  • Li-Fen Ye
  • Yong Fan
  • Qiang Shu
  • Ru LinEmail author
Clinical summary



To summarize the experience of management of persistent pulmonary hypertension of the newborn (PPHN) with extracorporeal membrane oxygenation (ECMO) support.


We presented three neonates with PPHN supported by ECMO in our center. Medical records and patient management notes were retrospectively reviewed.


For two neonates with congenital diaphragmatic hernia (CDH), diaphragm repair surgery was done under ECMO support. One patient was weaned from ECMO after 73 hours, and recovered well at the last follow-up after 1 year. The other patient was weaned from ECMO after 167 hours, and he died from septic shock 21 days after decannulation. For the neonate with idiopathic PPHN, ECMO was withdrawn successfully.


ECMO is an effective rescue means for refractory PPHN. Appropriate intervention timing, accurate coagulation, and volume management are important.


Extracorporeal membrane oxygenation Persistent pulmonary hypertension of the newborn 



We thank the ECMO team members at the Children’s Hospital, Zhejiang University School of Medicine. We thank the NICU and CCU physicians and nurses at Children’s Hospital, Zhejiang University School of Medicine, for their cooperation. No financial benefits have been received from any party related directly or indirectly to the subject of this article.

Author contributions

YLF designed the study, collected, and analyzed the medical records, and wrote the paper. LR and SQ designed the study and managed the writing. FY collected the medical records.


National Science and Technology Foundation of China (2012BAI04B05), Science and Technology Planning Project of Zhejiang Province, China (LGF18H020005).

Compliance with ethical standards

Ethical approval

This article was approved by the Ethics Committee of the Children’s Hospital of Zhejiang University School of Medicine. 

Conflict of interest

None declared.

Informed consent

Written informed consents for reporting these cases were obtained from their parents.


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2019

Authors and Affiliations

  1. 1.Heart Institute, Children’s HospitalZhejiang University School of MedicineHangzhouChina

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