World Journal of Pediatrics

, Volume 14, Issue 6, pp 541–547 | Cite as

Advances in diagnosis of chronic liver diseases in pediatric patients

  • Lucija RuzmanEmail author
  • Ivana Mikolasevic
  • Kristina Baraba Dekanic
  • Sandra Milic
  • Goran Palcevski
Review Article



Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recognition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available.


A non-systematic literature search was performed to summarize the current knowledge about transient elastography (TE) with controlled attenuation parameter (CAP) in children with CLD. Ovid MEDLINE, Ovid EMBASE, Google scholar, and The Cochrane Library databases were searched for relevant articles evaluating TE in the pediatric population.


Normal values of liver stiffness measurements (LSM) according to the age are given, as well as the advantages and disadvantages of the method. The utility of TE in specific liver disease in pediatric population is summarized.


TE with CAP is a valuable non-invasive method for the liver-damage assessment. Clinical interpretation of TE results should be made in parallel with the assessment of the patient’s demographics, disease etiology, and essential laboratory parameters.


Child Liver disease Liver stiffness Pediatric Transient elastography 


Author contributions

All authors have contributed to conception, drafting, and revision of the article. The final version has been read and approved by all authors.



Compliance with ethical standards

Ethical approval

Not required for this review article.

Conflict of interest


Supplementary material

12519_2018_197_MOESM1_ESM.docx (40 kb)
Supplementary material 1 (DOCX 40 kb)


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2018

Authors and Affiliations

  1. 1.Pediatric ClinicUHC RijekaRijekaCroatia
  2. 2.Department of GastroenterologyUHC RijekaRijekaCroatia
  3. 3.Pediatric Clinic, Department of GastroenterologyUHC RijekaRijekaCroatia

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