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World Journal of Pediatrics

, Volume 14, Issue 5, pp 504–509 | Cite as

Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts

  • Maximiliane I. Minderjahn
  • Dag Schädlich
  • Josephine Radtke
  • Karin Rothe
  • Marc Reismann
Original Article
  • 114 Downloads

Abstract

Background

Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immunological mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies.

Methods

White blood cell counts of patients aged between 7 and 14 years who underwent appendectomy from January 2008 to June 2016 were investigated with special reference to particular cellular subpopulations.

Results

A total of 647 children were included in the study. Within distinct inflammatory patterns, significant eosinophilia and basophilia were found in phlegmonous inflammation compared with complicated inflammation (0.11 ± 0.19 × 109/L vs. 0.046 ± 0.104 × 109/L, P < 0.0001, and 0.033 ± 0.031 × 109/L vs. 0.028 ± 0.024 × 109/L, P < 0.001).

Conclusions

Compared with complicated disease, phlegmonous appendicitis seems to depend primarily on eosinophil inflammation. This observation is stable over time and indicates a direction for investigation of underlying genetic prerequisites.

Keywords

Appendicitis Children Eosinophil granulocytes Immunology 

Notes

Author contributions

Study conception and design: MR, MIM, JR, KR. Acquisition of data: MR, MIM, DS. Analysis and interpretation of data: MR, MIM, JR. Drafting the manuscript: MR, MIM.

Funding

None.

Compliance with ethical standards 

Ethical approval

Ethical approval for our study was obtained within the general regulations for retrospektive studies without relevance for diagnostics or treatment. General consent for the use of data for scientific evaluation had been obtained within hospital admission.

Conflict of interest

No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. All authors declare that they have no conflict of interest.

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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2018
corrected publication September 2018

Authors and Affiliations

  • Maximiliane I. Minderjahn
    • 1
  • Dag Schädlich
    • 1
  • Josephine Radtke
    • 1
  • Karin Rothe
    • 1
  • Marc Reismann
    • 1
  1. 1.Department of Pediatric SurgeryCharité–Universitätsmedizin BerlinBerlinGermany

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