Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts
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Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immunological mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies.
White blood cell counts of patients aged between 7 and 14 years who underwent appendectomy from January 2008 to June 2016 were investigated with special reference to particular cellular subpopulations.
A total of 647 children were included in the study. Within distinct inflammatory patterns, significant eosinophilia and basophilia were found in phlegmonous inflammation compared with complicated inflammation (0.11 ± 0.19 × 109/L vs. 0.046 ± 0.104 × 109/L, P < 0.0001, and 0.033 ± 0.031 × 109/L vs. 0.028 ± 0.024 × 109/L, P < 0.001).
Compared with complicated disease, phlegmonous appendicitis seems to depend primarily on eosinophil inflammation. This observation is stable over time and indicates a direction for investigation of underlying genetic prerequisites.
KeywordsAppendicitis Children Eosinophil granulocytes Immunology
Study conception and design: MR, MIM, JR, KR. Acquisition of data: MR, MIM, DS. Analysis and interpretation of data: MR, MIM, JR. Drafting the manuscript: MR, MIM.
Compliance with ethical standards
Ethical approval for our study was obtained within the general regulations for retrospektive studies without relevance for diagnostics or treatment. General consent for the use of data for scientific evaluation had been obtained within hospital admission.
Conflict of interest
No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. All authors declare that they have no conflict of interest.
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