Netherlands Heart Journal

, Volume 21, Issue 4, pp 173–174 | Cite as

Postmenopausal sex hormones: comparing apples and pears

  • Y. AppelmanEmail author
  • C. B. Lambalk
Editorial Comment

The sex hormone story in relation to cardiovascular disease is always good for a surprise. Where we assumed that increased levels of female sex hormones were protective against the development of cardiovascular disease, our colleagues Mei Dong et al. from Yantai, China suggest quite the opposite. In their paper published in this edition of the Netherlands Heart Journal the authors describe a relation between the occurrence of a myocardial infarction (MI) in post-menopausal women and levels of sex hormones [1]. They report that high levels of oestradiol and increased waist-to-hip ratio (WHR) are related to the occurrence of acute MI.

This story is confusing. From an epidemiological perspective it was shown that in women there is a relation between the onset of the menopause and the risk of MI. Based on these observations studies were initiated to supply sex hormones in order to postpone the onset of atherosclerosis. Yet the beneficial effects of hormone replacement therapy were off set...




Conflict of interests

None declared.


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Copyright information

© The Author(s) 2013

Authors and Affiliations

  1. 1.Department of Cardiology 5F020VU University Medical CenterAmsterdamthe Netherlands
  2. 2.Department of Obstretics, Gynecology and Reproductive MedicineVU University Medical CenterAmsterdamthe Netherlands

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