Advertisement

Correlates of nicotine dependence in men with childhood attention-deficit/hyperactivity disorder: a 33-year follow-up

  • Lourdes García Murillo
  • María A. Ramos-Olazagasti
  • Rachel G. Klein
  • Salvatore Mannuzza
  • Francisco Xavier CastellanosEmail author
Original Article
  • 106 Downloads

Abstract

Identify correlates of nicotine dependence [lifetime (l) and ongoing (o)] in adults with attention-deficit/hyperactivity disorder (ADHD) in childhood. We conducted a 33-year prospective follow-up of boys (mean age 8) with combined type ADHD (n = 135/207, 65% original sample). Correlates of nicotine dependence in adulthood were selected from characteristics obtained in childhood and adolescence. Among selected childhood features, only immature behavior was significantly related to nicotine dependence (OR(o) = 0.29, p = 0.02), indexing decreased risk. In contrast, several adolescent variables significantly correlated (p < 0.01) with nicotine dependence at mean age 41, including alcohol substance use disorder (SUD, OR(l) = 4.97), non-alcohol SUD (OR(o) = 4.33/OR(l) = 10.93), parental antisocial personality disorder (OR(l) = 4.42), parental SUD (OR(l) = 3.58), dropped out of school (OR(l) = 2.29), impulsivity (OR(o) = 1.53/OR(l) = 1.59), hyperactivity (OR(o) = 1.38), and number of antisocial behaviors (OR(o) = 1.10/OR(l) = 1.14). Results highlight the role of adolescent psychopathology in the development of nicotine dependence, motivating prospective longitudinal efforts to better define the developmental trajectories of risk and protection.

Keywords

ADHD Prediction Nicotine dependence Longitudinal method 

Notes

Acknowledgements

This research was supported by NIH Grants R01MH18579 (RGK) and T32 MH067763 and R01DA016979 (FXC). LGM was supported by an Advanced Training Fellowship from the Alicia Koplowitz Foundation, Spain. Authors thank the Alicia Koplowitz Foundation for supporting Child and Adolescent Psychiatry.

Compliance with ethical standards

Conflict of interest

None of the authors have any financial interest in relation to this study or its results.

References

  1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, WashingtonGoogle Scholar
  2. Burke JD, Loeber R, Lahey BB (2001) Which aspects of ADHD are associated with tobacco use in early adolescence? J Child Psychol Psychiatry 42(4):493–502CrossRefGoogle Scholar
  3. Centers for Disease Control and Prevention (2014) Current cigarette smoking among adults—United States, 2005–2013. Centers for Disease Control and Prevention, New YorkGoogle Scholar
  4. Charach A, Yeung E, Climans T, Lillie E (2011) Childhood attention-deficit/hyperactivity disorder and future substance use disorders: comparative meta-analyses. J Am Acad Child Adolesc Psychiatry 50(1):9–21CrossRefGoogle Scholar
  5. Elkins IJ, McGue M, Iacono WG (2007) Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. Arch Gen Psychiatry 64(10):1145–1152CrossRefGoogle Scholar
  6. Fergusson DM, Horwood LJ, Ridder EM (2007) Conduct and attentional problems in childhood and adolescence and later substance use, abuse and dependence: results of a 25-year longitudinal study. Drug Alcohol Depend 88(Supplement 1):S14–S26CrossRefGoogle Scholar
  7. First MB, Spitzer Robert L, Miriam Gibbon, Williams Janet BW (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition. (SCID-I/NP). New York State Psychiatric Institute, Biometrics Research, New YorkGoogle Scholar
  8. Gittelman R, Abikoff H, Pollack E, Klein DF, Katz S, Mattes J (1980) A controlled trial of behavior modification and methylphenidate in hyperactive children. In: Whalen BHC (ed) Hyperactive children: the social ecology of identification and treatment. Academic Press, New York, pp 221–243Google Scholar
  9. Gittelman R, Mannuzza S, Shenker R, Bonagura N (1985) Hyperactive boys almost grown up. I. Psychiatric status. Arch Gen Psychiatry 42(10):937–947CrossRefGoogle Scholar
  10. Gittelman-Klein R, Klein DF (1975) Are behavioral and psychometric changes related in methylphenidate treated, hyperactive children? Int J Ment Health 4(1/2):182–198CrossRefGoogle Scholar
  11. Gittelman-Klein R, Klein DF, Abikoff H, Katz S, Gloisten AC, Kates W (1976a) Relative efficacy of methylphenidate and behavior modification in hyperkinetic children: an interim report. J Abnorm Child Psychol 4(4):361–379CrossRefGoogle Scholar
  12. Gittelman-Klein R, Klein DF, Katz S, Saraf K, Pollack E (1976b) Comparative effects of methylphenidate and thioridazine in hyperkinetic children. I. Clinical results. Arch Gen Psychiatry 33(10):1217–1231CrossRefGoogle Scholar
  13. Karp I, O’Loughlin J, Paradis G, Hanley J, Difranza J (2005) Smoking trajectories of adolescent novice smokers in a longitudinal study of tobacco use. Ann Epidemiol 15(6):445–452CrossRefGoogle Scholar
  14. Klein RG, Mannuzza S, Olazagasti MA, Roizen E, Hutchison JA, Lashua EC et al (2012) Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry 69(12):1295–1303CrossRefGoogle Scholar
  15. Lee SS, Humphreys KL, Flory K, Liu R, Glass K (2011) Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review. Clin Psychol Rev 31(3):328–341CrossRefGoogle Scholar
  16. Mannuzza S, Klein RG, Bonagura N, Malloy P, Giampino TL, Addalli KA (1991) Hyperactive boys almost grown up. V. Replication of psychiatric status. Arch Gen Psychiatry 48(1):77–83CrossRefGoogle Scholar
  17. Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50(7):565–576CrossRefGoogle Scholar
  18. Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M (1998) Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry 155(4):493–498CrossRefGoogle Scholar
  19. Mannuzza S, Castellanos FX, Roizen ER, Hutchison JA, Lashua EC, Klein RG (2011) Impact of the impairment criterion in the diagnosis of adult ADHD: 33-year follow-up study of boys with ADHD. J Atten Disord 15(2):122–129CrossRefGoogle Scholar
  20. Pingault JB, Cote SM, Galera C, Genolini C, Falissard B, Vitaro F et al (2013) Childhood trajectories of inattention, hyperactivity and oppositional behaviors and prediction of substance abuse/dependence: a 15-year longitudinal population-based study. Mol Psychiatry 18(7):806–812CrossRefGoogle Scholar
  21. Ramos Olazagasti MA, Klein RG, Mannuzza S, Belsky ER, Hutchison JA, Lashua-Shriftman EC et al (2013) Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood? J Am Acad Child Adolesc Psychiatry 52(2):153.e154–162.e154CrossRefGoogle Scholar
  22. Robins LN, Helzer JE, Croughan J, Ratcliff KS (1981) National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Arch Gen Psychiatry 38(4):381–389CrossRefGoogle Scholar
  23. Rodriguez D, Tercyak KP, Audrain-McGovern J (2008) Effects of inattention and hyperactivity/impulsivity symptoms on development of nicotine dependence from mid adolescence to young adulthood. J Pediatr Psychol 33(6):563–575CrossRefGoogle Scholar
  24. U.S. Department of Health and Human Services (2014) The health consequences of smoking—50 years of progress. U.S. Department of Heath and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office of Smoking and HealthGoogle Scholar
  25. Wechsler D (1974) Wechsler Intelligence Scale for Children, revised. Psychological Corporation, New YorkGoogle Scholar
  26. Whelan R, Watts R, Orr CA, Althoff RR, Artiges E, Banaschewski T et al (2014) Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature 512(7513):185–189CrossRefGoogle Scholar
  27. World Health Organization (2013) WHO report on the global tobacco epidemic, 2013: enforcing bans on tobacco advertising, promotion and sponsorship. World Health Organization, GenevaGoogle Scholar
  28. World Health Organization (2015) WHO report on the global tobacco epidemic, 2015: World Health Organization. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Lourdes García Murillo
    • 1
    • 2
  • María A. Ramos-Olazagasti
    • 3
    • 4
  • Rachel G. Klein
    • 2
    • 5
  • Salvatore Mannuzza
    • 2
  • Francisco Xavier Castellanos
    • 2
    • 5
    Email author
  1. 1.Department of PsychiatryHospital Universitario Puerta de Hierro MajadahondaMadridSpain
  2. 2.Department of Child and Adolescent Psychiatry, Child Study CenterHassenfeld Children’s Hospital at NYU LangoneNew YorkUSA
  3. 3.Reproductive Health and Family Formation and Hispanic InstituteChild TrendsBethesdaUSA
  4. 4.Department of PsychiatryColumbia University Medical CenterNew YorkUSA
  5. 5.Nathan Kline Institute for Psychiatric ResearchOrangeburgUSA

Personalised recommendations