Light-chain cardiac amyloidosis: A multimodality approach
- 19 Downloads
Amyloidosis is a multisystemic disease, caused by deposits of misfolded protein fragments. There are two main types of amyloidosis, the light-chain (AL) and transthyretin-related amyloidosis, both of them, affect the heart. Cardiac affection usually manifests with heart failure. The non-invasive diagnostic methods used to establish the diagnosis are echocardiography, cardiac magnetic resonance (CMR) and pyrophosphate scintigraphy.1-3 Endomyocardial biopsy is the gold standard for diagnosis of cardiac amyloidosis, however, CMR, single-photon emission computed tomography using specific amyloid radiotracers have been shown to have high sensitivity and specificity.2,3
A 59-year-old male came to the emergency room with dyspnea on exertion, orthopnea and precordial stabbing pain. On physical examination, a jugular plethora and holosystolic and meso-diastolic murmur were detected in the apex. Electrocardiogram in sinus rhythm, with flat T-waves, necrosis of...
Erick Alexanderson-Rosas, Mara Escudero-Salamanca, Jesus A Garcia-Diaz, Ricardo Alvarez-Santana, Roberto Cano-Zarate, Julio Mamani-Tito, Isabel Carvajal-Juarez, Nilda Espinola-Zavaleta have no disclosure to declare.