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Non-biopsy diagnosis of familial amyloid cardiomyopathy

  • Laroussi Mohamed-SalemEmail author
  • Tatiana Moreno-Monsalve
  • Mª Isabel Castellón-Sánchez
  • Mª Antonia Claver-Valderas
  • Domingo Pascual-Figal
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An 84-year-old male, former smoker yet without other cardiovascular risk factors, has a history of carpal tunnel syndrome, chronic axonal sensorimotor polyneuropathy moderate to a severe degree, more prominent in the lower extremities, colonic diverticulosis, and large internal hemorrhoids. The patient has a family history of cardiomyopathy, with both fathers and five of his seven brothers died of cardiomyopathy, an unknown etiological diagnosis.

During 2016, he was admitted to internal medicine for dyspnea, with a diagnosis on discharge of heart failure with evidence of myocardial amyloidosis. Several examinations yielded the following results: normal blood cell count, normal liver and kidney function, normal serum protein and immunochemistry, free kappa chains 27.5 (increased), lambda chains and normal ratio (k/l 1.7), selective glomerular proteinuria without Bence Jones proteinuria, and negative Chagas serology.

Transthoracic echocardiogram pointed out non-dilated left ventricle,...

Notes

Disclosure

The authors have nothing to disclose.

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Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  • Laroussi Mohamed-Salem
    • 1
    Email author
  • Tatiana Moreno-Monsalve
    • 1
  • Mª Isabel Castellón-Sánchez
    • 1
  • Mª Antonia Claver-Valderas
    • 1
  • Domingo Pascual-Figal
    • 2
  1. 1.Department of Nuclear MedicineHospital Clinico Universitario Virgen de la ArrixacaMurciaSpain
  2. 2.Department of CardiologyHospital Clinico Universitario Virgen de la ArrixacaMurciaSpain

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