Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging
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The aim of the study was to assess the agreement between the left ventricular ejection fraction (LVEF) values obtained with IQ-SPECT and those obtained with a conventional gamma camera equipped with low-energy high-resolution (LEHR), considered as the method of reference.
Gated-stress MPI using 99mTc-tetrofosmin was performed in 55 consecutive patients. The patients underwent two sequential acquisitions (Method A and B) performed on Symbia-IQ SPECT with different acquisition times and one (Method C) on a Ecam SPECT equipped with LEHR collimators. The values of the different datasets were compared using the Bland-Altman analysis method: the bias and the limits of agreement (LA) were estimated in a head-to-head comparison of the three protocols.
In the (Method A-Method C) comparison for LVEF, the bias was 3.8% and the LAs ranged from − 9.3% to 16.8%. The agreement was still lower between Method B and C, whilst only slightly improved when Methods A and B were compared.
The wide amplitude in LA intervals of about 30% indicates that IQ and LEHR GSPECT are not interchangeable. The values obtained with IQ-SPECT should only be used with caution when evaluating the functional state of the heart.
KeywordsCAD gated SPECT instrumentation perfusion agents statistical analysis
End diastolic volume
End systolic volume
Filtered back projection
Limits of agreement
Left ventricular ejection fraction
Myocardial perfusion imaging
We would like to thank Clizia Dionisi (MSc) for her valuable contribution in the collection of data.
No potential conflict of interest relevant to this article was reported.
Study concept and design: M. Brambilla, L. Leva, R. Matheoud. Data acquisition: L. Leva, G. Sacchetti, R. Matheoud. Analysis and interpretation of data: M. Brambilla, L. Leva, R. Matheoud, A. Carriero. Drafting of the manuscript: M. Brambilla, R. Matheoud, L. Leva. Clinical revision of the manuscript for important intellectual content: L. Leva, G. Sacchetti, A. Carriero. Final approval of the manuscript submitted: all authors.
- 2.Ficaro EP, Quaife RA, Kritzman JN, Corbett JR. Accuracy of reproducibility of 3D-MSPECT for estimating left ventricular ejection fraction in patients with severe perfusion abnormalities. Circulation 1999;100:I26.Google Scholar
- 4.Ziada G, Mohamed MM, Hayat N, Yousof AM, Abdel-Dayem HM, Bahar R, et al. Quantitative analysis of cardiac function: Comparison of electro-cardiogram dual gated single photon emission tomography, planar radionuclide ventriculogram and contrast ventriculography in the determination of LV volume and ejection fraction. Eur J Nucl Med 1987;12:592-7.CrossRefGoogle Scholar
- 6.Lipke CS, Kühl HP, Nowak B, Kaiser HJ, Reinartz P, Koch KC. Validation of 4D-MSPECT and QGS for quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPET: Comparison with cardiac magnetic resonance imaging. Eur J Nucl Med Mol Imaging 2004;31:482-90.CrossRefGoogle Scholar
- 10.Zeintl J, Rempel TD, Bhattacharya M, Malmin RE, Vija AH. Performance characteristics of the SMARTZOOM collimator. In: Nuclear science symposium and medical imaging conference, 2011. pp. 2426-29.Google Scholar
- 11.Vija AH, Malmin R, Yahil A, Zeintl J, Bhattacharya M, Rempel TD, et al. A method for improving the efficiency of myocardial perfusion imaging using conventional SPECT and SPECT/CT imaging systems. In: Nuclear science symposium and medical imaging conference, 2010. pp. 3433-37.Google Scholar
- 20.Lange K, Carson R. EM reconstruction algorithms for emission and transmission tomography. J Comput Assist Tomogr 1984;8:306-16.Google Scholar
- 29.Pirich C, Keinrath P, Barth G, Rendl G, Rettenbacher L, Rodrigues M. Diagnostic accuracy and functional parameters of myocardial perfusion scintigraphy using accelerated cardiac acquisition with IQ SPECT technique in comparison to conventional imaging. Q J Nucl Med Mol Imaging 2017;61:102-7.PubMedGoogle Scholar