FMTVDM-TFM©℗: True quantification requires standardization of the tool being used to measure, with a known, unchanging standard to produce accurate, consistent and reproducible quantified measurements
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Everyone is beginning to understand the importance of quantification for use in Medicine, particularly Molecular Imaging. With the recent introduction of mandates by CMS, ASNC and the SNMMI for Quantification, it is not surprising that papers are being published on the topic. One recent publication by Zhao et al1 demonstrates that there may be misunderstandings regarding modern molecular imaging.
The Misunderstanding of Quantification
Quantification is not asking whether a tool can count, but rather whether the tool can count accurately. The Zhao paper presents several methods using phantoms and display “counts” of isotope scintillation activity, reporting on the ability of the cameras to count. Concluding that there is a camera calibration factor, which must be applied, there is an example regarding the counts obtained using a point source with a SPECT camera. When the SPECT camera was asked to count over time2,3using a 128 × 128 matrix setting, there was a 14.6% reduction in...
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