Journal of Nuclear Cardiology

, Volume 26, Issue 1, pp 337–341 | Cite as

Isolated cardiac amyloidosis. Utility of bone seeking tracers scintigraphy in differentiating the subtype of amyloid: A case report

  • O. BourogianniEmail author
  • E. Papadaki
  • E. Foukarakis
  • S. Koukouraki
Images that Teach



Three types of amyloid are responsible for cardiac amyloidosis. Differentiation of the subtype is critical for the disease progression and the therapeutic decision.


Myocardial scintigraphy using Tc-PYP is able to differentiate the cardiac amyloid subtype with high sensitivity and specificity. The myocardial uptake of PYP is higher in patients with TTR amyloidosis.


Non-invasive tests for the detection of cardiac amyloidosis, like myocardial scintigraphy with bone seeking tracers, can play a major role in the diagnosis progression and therapeutic management of patients with cardiac amyloidosis.


Heart failure SPECT 99mTc 



Transthyretin-related amyloidosis


Senile systemic amyloidosis


Light chain amyloidosis


Cardiac magnetic resonance imaging


Transthoracic echocardiogram


Right ventricular


Left ventricular


Heart to contralateral




Hereditary transthyretin amyloidosis



O. Bourogianni, E. Papadaki, E. Foukarakis and S. Koukouraki as authors of this case report have nothing to declare.


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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • O. Bourogianni
    • 1
    Email author
  • E. Papadaki
    • 1
  • E. Foukarakis
    • 2
  • S. Koukouraki
    • 1
  1. 1.Department of Nuclear Medicine, Medical SchoolUniversity of CreteHeraklionGreece
  2. 2.Department of CardiologyVenizeleion General HospitalHeraklionGreece

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