Advertisement

Drivers of radiation dose reduction with myocardial perfusion imaging: A large health system experience

  • Firas J. Al BadarinEmail author
  • John A. Spertus
  • Timothy M. Bateman
  • Krishna K. Patel
  • Eric V. Burgett
  • Kevin F. Kennedy
  • Randall C. Thompson
Original Article
  • 23 Downloads

Abstract

Background

Despite increasing emphasis on reducing radiation exposure from myocardial perfusion imaging (MPI), the use of radiation-sparing practices (RSP) at nuclear laboratories remains limited. Defining real-world impact of RSPs on effective radiation dose (E) can potentially further motivate their adoption.

Methods

MPI studies performed between 1/2010 and 12/2016 within a single health system were included. Mean E was compared between sites with ‘basic’ RSP (defined as elimination of thallium-based protocols and use of stress-only (SO) imaging on conventional single photon emission computed tomography (SPECT) cameras) and those with ‘advanced’ capabilities (sites that additionally used solid-state detector (SSD) SPECT cameras, advanced post-processing software (APPS) or positron emission tomography (PET) imaging), after matching patients by age, gender, and weight. Contributions of individual RSP to E reduction were determined using multiple linear regression after adjusting for factors affecting tracer dose.

Results

Among 55,930 MPI studies performed, the use of advanced RSP was associated with significantly lower mean E compared to basic RSP (7 ± 5.6 mSv and 16 ± 5.4 mSv, respectively; P < 0.001), with a greater likelihood of achieving E < 9 mSv (65.7% vs. 10.8%, respectively; OR 15.8 [95% CI 14 to 17.8]; P < 0.0001). Main driver of E reduction was SO-SSD SPECT (mean reduction = 11.5 mSv), followed by use of SO-SPECT + APPS (mean reduction = 10.1 mSv), ;ET (mean reduction = 9.7 mSv); and elimination of thallium protocols (mean reduction = 9.1 mSv); P < 0.0001 for all comparisons.

Conclusion

In a natural experiment with implementation of radiation-saving practices at a large health system, stress-only protocols used in conjunction with modern SPECT technologies, the use of PET and elimination of thallium-based protocols were associated with greatest reductions in radiation dose. Availability of several approaches to dose reduction within a health system can facilitate achievement of targeted radiation benchmarks in a greater number of performed studies.

Keywords

Myocardial perfusion imaging radiation exposure effective dose 

Abbreviations

CAD

Coronary artery disease

E

Effective dose

MPI

Myocardial perfusion imaging

PET

Positron emission tomography

RSP

Radiation-sparing practices

SO

Stress-only

SPECT

Single photon emission computed tomography

SSD

Solid-state detector

Notes

Disclosures

Drs. Patel and Al Badarin are supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number T32HL110837. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr. Spertus receives research grant support from Abbott Vascular, Novartis, and is the PI of an analytic center for the American College of Cardiology. He serves as a consultant to the United Healthcare, Bayer, Janssen, AstraZeneca, and Novartis. He has an equity interest in the Health Outcomes Sciences. Dr. Bateman receives research grant support from Astellas and GE Healthcare. He serves as a consultant to GE Healthcare. He has ownership interest in Cardiovascular Imaging Technologies. He has intellectual property rights for Imagen Pro/MD/Q/3D software. The other authors have no conflicts of interest to disclose.

Supplementary material

12350_2018_1576_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 14 kb)
12350_2018_1576_MOESM2_ESM.docx (15 kb)
Supplementary material 2 (DOCX 15 kb)
12350_2018_1576_MOESM3_ESM.pptx (708 kb)
Supplementary material 3 (PPTX 708 kb)

References

  1. 1.
    Chen J, Einstein AJ, Fazel R, Krumholz HM, Wang Y, Ross JS, Ting HH, Shah ND, Nasir K, Nallamothu BK. Cumulative exposure to ionizing radiation from diagnostic and therapeutic cardiac imaging procedures: a population-based analysis. J Am Coll Cardiol 2010;56:702-11.CrossRefGoogle Scholar
  2. 2.
    Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ. Radiation dose to patients from cardiac diagnostic imaging. Circulation 2007;116:1290-305.CrossRefGoogle Scholar
  3. 3.
    Einstein AJ, Weiner SD, Bernheim A, Kulon M, Bokhari S, Johnson LL, Moses JW, Balter S. Multiple testing, cumulative radiation dose, and clinical indications in patients undergoing myocardial perfusion imaging. JAMA 2010;304:2137-44.CrossRefGoogle Scholar
  4. 4.
    Cerqueira MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, Van Decker WA, Yakovlevitch M. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol 2010;17:709-18.CrossRefGoogle Scholar
  5. 5.
    Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39.CrossRefGoogle Scholar
  6. 6.
    Einstein AJ, Berman DS, Min JK, Hendel RC, Gerber TC, Carr JJ, Cerqueira MD, Cullom SJ, DeKemp R, Dickert NW, Dorbala S, Fazel R, Garcia EV, Gibbons RJ, Halliburton SS, Hausleiter J, Heller GV, Jerome S, Lesser JR, Raff GL, Tilkemeier P, Williams KA, Shaw LJ. Patient-centered imaging: shared decision making for cardiac imaging procedures with exposure to ionizing radiation. J Am Coll Cardiol 2014;63:1480-9.CrossRefGoogle Scholar
  7. 7.
    Dorbala S, Blankstein R, Skali H, Park MA, Fantony J, Mauceri C, Semer J, Moore SC, Di Carli MF. Approaches to reducing radiation dose from radionuclide myocardial perfusion imaging. J Nucl Med 2015;56:592-9.CrossRefGoogle Scholar
  8. 8.
    Bateman TM, Heller GV, McGhie AI, Courter SA, Golub RA, Case JA, Cullom SJ. Multicenter investigation comparing a highly efficient half-time stress-only attenuation correction approach against standard rest-stress Tc-99 m SPECT imaging. J Nucl Cardiol 2009;16:726-35.CrossRefGoogle Scholar
  9. 9.
    Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, Hutton B, Sharir T, Haim SB, Haim SB. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med 2009;50:635-43.CrossRefGoogle Scholar
  10. 10.
    Lyon MC, Foster C, Ding X, Dorbala S, Spence D, Bhattacharya M, Vija AH, DiCarli MF, Moore SC. Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation. J Nucl Cardiol 2016;23:657-67.CrossRefGoogle Scholar
  11. 11.
    Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Dondi M, Paez D, Einstein AJ, Group II. Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the united states and worldwide. JAMA Intern Med 2016;176:269-73.CrossRefGoogle Scholar
  12. 12.
    Tout D, Davidson G, Hurley C, Bartley M, Arumugam P, Bradley A. Comparison of occupational radiation exposure from myocardial perfusion imaging with Rb-82 PET and Tc-99 m SPECT. Nucl Med Commun 2014;35:1032-7.CrossRefGoogle Scholar
  13. 13.
    Einstein AJ, Pascual TN, Mercuri M, Karthikeyan G, Vitola JV, Mahmarian JJ, Better N, Bouyoucef SE, Hee-Seung Bom H, Lele V, Magboo VP, Alexanderson E, Allam AH, Al-Mallah MH, Flotats A, Jerome S, Kaufmann PA, Luxenburg O, Shaw LJ, Underwood SR, Rehani MM, Kashyap R, Paez D, Dondi M, Group II. Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS). Eur Heart J 2015;36:1689-96.CrossRefGoogle Scholar
  14. 14.
    Jerome SD, Tilkemeier PL, Farrell MB, Shaw LJ. Nationwide laboratory adherence to myocardial perfusion imaging radiation dose reduction practices: A report from the intersocietal accreditation commission data repository. JACC Cardiovasc Imaging 2015;8:1170-6.CrossRefGoogle Scholar
  15. 15.
    Lindner O, Pascual TN, Mercuri M, Acampa W, Burchert W, Flotats A, Kaufmann PA, Kitsiou A, Knuuti J, Underwood SR, Vitola JV, Mahmarian JJ, Karthikeyan G, Better N, Rehani MM, Kashyap R, Dondi M, Paez D, Einstein AJ. Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries. Eur J Nucl Med Mol Imaging 2016;43:718-28.CrossRefGoogle Scholar
  16. 16.
    Otsuka R, Kubo N, Miyazaki Y, Kawahara M, Takaesu J, Fukuchi K. Current status of stress myocardial perfusion imaging pharmaceuticals and radiation exposure in Japan: Results from a nationwide survey. J Nucl Cardiol 2017;24:1850-5.CrossRefGoogle Scholar
  17. 17.
    Mercuri M, Pascual TN, Mahmarian JJ, Shaw LJ, Rehani MM, Paez D, Einstein AJ, Group II. Comparison of radiation doses and best-practice use for myocardial perfusion imaging in US and non-US laboratories: Findings from the IAEA (International Atomic Energy Agency) Nuclear Cardiology Protocols Study. JAMA Intern Med 2016;176:266-9.CrossRefGoogle Scholar
  18. 18.
    Thompson RC, O’Keefe JH, McGhie AI, Bybee KA, Thompson EC, Bateman TM. Reduction of SPECT MPI radiation dose using contemporary protocols and technology. JACC Cardiovasc Imaging 2018;11:282-3.CrossRefGoogle Scholar
  19. 19.
    Songy B, Guernou M, Hivoux D, Attias D, Lussato D, Queneau M, Bonardel G, Bertaux M. Prognostic value of one millisievert exercise myocardial perfusion imaging in patients without known coronary artery disease. J Nucl Cardiol 2018;25:120-30.CrossRefGoogle Scholar
  20. 20.
    Dorbala S, Di Carli MF, Delbeke D, Abbara S, DePuey EG, Dilsizian V, Forrester J, Janowitz W, Kaufmann PA, Mahmarian J, Moore SC, Stabin MG, Shreve P. SNMMI/ASNC/SCCT guideline for cardiac SPECT/CT and PET/CT 1.0. J Nucl Med 2013;54:1485-507.CrossRefGoogle Scholar
  21. 21.
    Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, Courter SA, Golub RJ, Case JA, Cullom SJ. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 2009;16:714-25.CrossRefGoogle Scholar
  22. 22.
    Gowd BM, Heller GV, Parker MW. Stress-only SPECT myocardial perfusion imaging: a review. J Nucl Cardiol 2014;21:1200-12.CrossRefGoogle Scholar
  23. 23.
    1990 Recommendations of the International Commission on Radiological Protection. Ann ICRP 1991;21:1-201.Google Scholar
  24. 24.
    Conversion coefficients for use in radiological protection against external radiation. Adopted by the ICRP and ICRU in September 1995. Ann ICRP 1996;26:1-205.Google Scholar
  25. 25.
    Case JA, deKemp RA, Slomka PJ, Smith MF, Heller GV, Cerqueira MD. Status of cardiovascular PET radiation exposure and strategies for reduction: An information statement from the cardiovascular PET Task Force. J Nucl Cardiol 2017;24:1427-39.CrossRefGoogle Scholar
  26. 26.
    Depuey EG, Mahmarian JJ, Miller TD, Einstein AJ, Hansen CL, Holly TA, Miller EJ, Polk DM, Samuel Wann L. Patient-centered imaging. J Nucl Cardiol 2012;19:185-215.CrossRefGoogle Scholar
  27. 27.

Copyright information

© American Society of Nuclear Cardiology 2019

Authors and Affiliations

  • Firas J. Al Badarin
    • 1
    • 2
    Email author
  • John A. Spertus
    • 1
    • 2
  • Timothy M. Bateman
    • 1
    • 2
    • 3
  • Krishna K. Patel
    • 1
    • 2
  • Eric V. Burgett
    • 1
  • Kevin F. Kennedy
    • 1
  • Randall C. Thompson
    • 1
    • 2
  1. 1.Department of Cardiovascular ResearchSaint Luke’s Mid America Heart InstituteKansas CityUSA
  2. 2.School of MedicineUniversity of Missouri- Kansas CityKansas CityUSA
  3. 3.Cardiovascular Imaging TechnologiesKansas CityUSA

Personalised recommendations