Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components

  • Francesco NudiEmail author
  • Giuseppe Biondi-Zoccai
  • Andrea Romagnoli
  • Orazio Schillaci
  • Alessandro Nudi
  • Francesco Versaci
Review Article


Coronary artery disease (CAD) is the most common and important cause of ischemic heart disease, with major implications on global morbidity and mortality. Non-invasive testing is crucial in the diagnostic and prognostic work-up of patients with or at risk of CAD, and also to guide decision making in terms of pharmacologic and revascularization therapy. The traditional paradigm is to view anatomic (i.e., coronary computed tomography) and functional imaging (e.g., myocardial perfusion scintigraphy) tests as opposing alternatives. Such approach is too reductionist and does not capitalize on the strengths of each type of test while risking to overlook the inherent limitations. The combination of anatomic and functional tests in a logic of hybrid imaging holds the promise of overcoming the limitations inherent to anatomic and functional testing, enabling more accurate diagnosis, prognosis, and guidance for revascularization in patients with CAD.


Coronary artery disease computed tomography hybrid imaging single-photon emission computed tomography 

Abbreviations and acronyms


Coronary artery disease


Cardiac magnetic resonance


Computed tomography


Computed tomography angiography


Computed tomography perfusion




Computed tomography fractional flow reserve


Positron emission tomography


Single-photon emission computed tomography


Synergy between PCI with Taxus and Cardiac Surgery



Prof. Biondi-Zoccai has consulted for Abbott Vascular and Bayer. Dr. F. Nudi, Prof. Romagnoli, Prof. Schillaci, Dr. A. Nudi, and Prof. Versaci have nothing to disclose.

Supplementary material

12350_2018_1562_MOESM1_ESM.pptx (1.6 mb)
Supplementary material 1 (PPTX 1634 kb)


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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Francesco Nudi
    • 1
    • 2
    • 3
    Email author
  • Giuseppe Biondi-Zoccai
    • 4
    • 5
  • Andrea Romagnoli
    • 6
  • Orazio Schillaci
    • 5
    • 7
  • Alessandro Nudi
    • 1
    • 3
  • Francesco Versaci
    • 8
  1. 1.Service of Hybrid Cardio ImagingMadonna Della Fiducia ClinicRomeItaly
  2. 2.Ostia RadiologicaRomeItaly
  3. 3.ReplycareRomeItaly
  4. 4.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeLatinaItaly
  5. 5.IRCCS NEUROMEDPozzilliItaly
  6. 6.Department of RadiologyTor Vergata UniversityRomeItaly
  7. 7.Department of Nuclear MedicineTor Vergata UniversityRomeItaly
  8. 8.Division of CardiologyS. Maria Goretti HospitalLatinaItaly

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