Cardiovascular disease in the literature: A selection of recent original research papers
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Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release. J Am Coll Cardiol 2018;72:2040–50.
Background: Bilateral carpal tunnel syndrome is common in patients with cardiac amyloidosis, especially the transthyretin type (TTR), and usually precedes it by 5-10 years. Sperry et al. from Cleveland Clinic Foundation, Ohio performed a cross-sectional prospective study of 98 patients (median age 68 years, 51% men, 85% bilateral symptoms) undergoing carpal tunnel release surgery to determine the prevalence and type of amyloid deposits in the tenosynovium in addition to cardiac involvement.
Findings:On tenosynovial biopsy, 10 patients (10.2%) had amyloid deposits by Congo red staining (7 ATTR and 2 AL by mass spectrometry). Of these 10 patients, 2 had cardiac amyloidosis; one had AL amyloid with increased septal thickness by echocardiography, elevated NT-proBNP and cardiac troponin T and heart failure by exam. The other patient had TTR amyloid with septal hypertrophy...