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Journal of Nuclear Cardiology

, Volume 26, Issue 1, pp 236–245 | Cite as

The effect of CT-based attenuation correction on the automatic perfusion score of myocardial perfusion imaging using a dedicated cardiac solid-state CZT SPECT/CT

  • John A. KennedyEmail author
  • Yafim Brodov
  • Adam L. Weinstein
  • Ora Israel
  • Alex Frenkel
Original Article

Abstract

Background

Data regarding cardiac cadmium-zinc-telluride (CZT)-specific augmented databases and their impact on CT-based attenuation correction (AC) perfusion scores in myocardial perfusion imaging (MPI) were obtained on a multiple-pinhole CZT SPECT/CT.

Methods and Results

Summed stress (SSS) and rest scores (SRS) were measured using automated software in three independent patient groups: group 1 (n = 80) underwent MPI on both CZT and conventional sodium iodide (NaI) devices, group 2 (n = 80) with low coronary artery disease likelihood and normal MPI provided reference CZT databases; and group 3 (n = 152) served to compare AC and non-AC (NAC) scores on CZT. Group 1 CZT and NaI scores gave a significant 1:1 linear correlation for CZT scores referenced to the custom database vs NaI scores referenced to the default database, but these were not concordant when CZT scores were referenced to the default database. AC significantly decreased average SSS and SRS in men vs NAC, 4.29 ± 6.30 vs 5.37 ± 7.26 (P < 0.001) and 2.37 ± 4.72 vs 3.13 ± 5.85 (P < 0.001), but not in women, 2.28 ± 3.42 vs 2.28 ± 3.08 (p NS) and 0.46 ± 1.51 vs 0.61 ± 1.86, (p NS), respectively.

Conclusions

Specifically designed databases for solid-state CZT cardiac SPECT provide accurate quantitation of perfusion scores concordant with those previously validated for conventional SPECT. AC and NAC CZT scores differed significantly, especially in men.

Keywords

Instrumentation: SPECT myocardial perfusion imaging: SPECT cadmium-zinc-telluride ultrafast cardiac gamma camera summed stress score 

Abbreviations

AC

Attenuation correction

CAD

Coronary artery disease

CTAC

Computed tomography-based attenuation correction

CZT

Cadmium-zinc-telluride

MPI

Myocardial perfusion imaging

NAC

No attenuation correction

NaI

Sodium iodide

SPECT

Single-photon emission computerized tomography

SRS

Summed rest score

SSS

Summed stress score

Notes

Disclosures

Ora Israel is a consultant to GE Healthcare. No other author has any financial disclosures in relationship to this study.

Supplementary material

12350_2017_905_MOESM1_ESM.pptx (556 kb)
Supplementary material 1 (PPTX 556 kb)

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Copyright information

© American Society of Nuclear Cardiology 2017

Authors and Affiliations

  • John A. Kennedy
    • 1
    • 2
    Email author
  • Yafim Brodov
    • 1
  • Adam L. Weinstein
    • 3
  • Ora Israel
    • 1
    • 3
  • Alex Frenkel
    • 1
  1. 1.Department of Nuclear MedicineRambam Health Care CampusHaifaIsrael
  2. 2.Faculty of Biomedical Engineering, TechnionIsrael Institute of TechnologyHaifaIsrael
  3. 3.B. and R. Rappaport School of Medicine, TechnionIsrael Institute of TechnologyHaifaIsrael

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