Journal of Nuclear Cardiology

, Volume 24, Issue 4, pp 1239–1245 | Cite as

Multi-modality molecular imaging of aortic aneurysms

  • Brian J. MalmEmail author
  • Mehran M. Sadeghi
Molecular Imaging Corner


Aneurysms of the thoracic and abdominal aorta are common and can be associated with significant morbidity and mortality when complications, including dissection, rupture, or thrombosis, occur. Current approaches to diagnosis and risk stratification rely on measurements of aneurysm size and rate of growth, often using various imaging modalities, which may be suboptimal in identifying patients at the highest and lowest risk of complications. Targeting the biological processes underlying aneurysm formation and expansion with molecular imaging offers an exciting opportunity to characterize aortic aneurysms beyond size and address current gaps in our approach to diagnosis and treatment. In this review, we summarize the epidemiology and biology of aortic aneurysms and highlight the role of molecular imaging in furthering our understanding of aneurysm pathogenesis and its potential future role in guiding management.


Molecular imaging FDG aneurysm PET SPECT matrix metalloproteinases 



Thoracic aortic aneurysm


Abdominal aortic aneurysm


Matrix metalloproteinases


Magnetic resonance


Single photon emission computed tomography


Positron emission tomography


Computed tomography




Ultrasmall superparamagnetic particles of iron oxide



No conflicts of interest to disclose.


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Copyright information

© American Society of Nuclear Cardiology 2017

Authors and Affiliations

  1. 1.Section of Cardiovascular MedicineYale University School of MedicineNew HavenUSA
  2. 2.Veterans Affairs Connecticut Healthcare SystemWest HavenUSA

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