Journal of Nuclear Cardiology

, Volume 24, Issue 4, pp 1178–1189 | Cite as

Catheter-based functional metrics of the coronary circulation

  • Panagiotis Xaplanteris
  • Emanuele Barbato
  • Bernard De BruyneEmail author
Review Article


In patients with stable chest pain, decision making about treatment strategy should be based on anatomical and functional information on the coronary circulation. Traditionally, the functional data are obtained by non-invasive testing which aims at detecting and localizing ‘myocardial ischemia.’ Yet, the diagnostic accuracy of diagnostic testing is over-rated in the literature, so that in clinical practice, a sizable proportion of patients undergo a coronary angiogram without prior useful functional information. Therefore, several methods have been developed to obtain similar information in the catheterization laboratory. Here we review briefly some of these methods. Some of them are used routinely in clinical practice, and others are under development.


Coronary angiogram coronary artery disease microcirculation coronary flow reserve fractional flow reserve ischemic testing index of microvascular resistance 



Coronary artery disease


Coronary flow reserve


Fractional flow reserve


Computed tomography-derived fractional flow reserve


Instantaneous wave-free ratio


Index of microvascular resistance


Intravascular ultrasound


Left anterior descending artery


Optical coherence tomography


Proximal (aortic) pressure


Distal coronary pressure


Coronary occlusive pressure


Venous pressure


Positron emission tomography




Quantitative coronary angiography




Randomized controlled trial


Mean transit time



Dr Xaplanteris has received research grants from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) and the Hellenic Cardiological Society (HCS) for 2016. Dr. Barbato reports institutional research grants and speaker’s fees from St. Jude Medical not related to this manuscript to the Cardiovascular Center Aalst. Dr. De Bruyne is a shareholder for Siemens,GE, Bayer, Philips, HeartFlow, Edwards Life Sciences, Sanofi, Omega Pharma; The Cardiovascular Center Aalst has received grant support from Abbott, Boston Scientific, Biotronik, and St Jude Medical and receives consulting fees on his behalf from St. Jude Medical, Opsens, and Boston Scientific outside of the submitted work.


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Copyright information

© American Society of Nuclear Cardiology 2016

Authors and Affiliations

  • Panagiotis Xaplanteris
    • 1
  • Emanuele Barbato
    • 1
  • Bernard De Bruyne
    • 1
    Email author
  1. 1.Cardiovascular Center AalstOLV-ClinicAalstBelgium

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