Advertisement

Journal of Nuclear Cardiology

, Volume 24, Issue 4, pp 1149–1156 | Cite as

Validation of early image acquisitions following Tc-99 m sestamibi injection using a semiconductors camera of cadmium-zinc-telluride

  • Celine MeyerEmail author
  • Pierre Weinmann
Original Article

Abstract

Background

Cadmium-zinc-telluride (CZT) cameras allow to decrease significantly the acquisition time of myocardial perfusion imaging (MPI), but the duration of the examination is still long. Therefore, this study was performed to test the feasibility of early imaging following injection of Tc-99 m sestamibi using a CZT camera.

Methods

Seventy patients underwent both an early and a delayed image acquisition after exercise stress test (n = 30), dipyridamole stress test (n = 20), and at rest (n = 20). After injection of Tc-99 m sestamibi, the early image acquisition started on average within 5 minutes for the exercise and rest groups, and 3 minutes 30 seconds for the dipyridamole group. Two independent observers evaluated image quality and extracardiac uptake on four-point scales. The difference between early and later images for each patient was scored on a five-point scale.

Results

The image quality and extracardiac uptake of early and delayed image acquisitions were not different for the three groups (P > .05). There was no significant difference between early and delayed image acquisitions in the exercise, dipyridamole, and rest groups, respectively, in 63%, 40%, and 80% of cases. In the exercise group and rest group, a defect was only present in early MPI, respectively, in 13% and 20% of cases. A defect was only present in delayed images in 10% of cases in the exercise group and in 45% of cases in the dipyridamole group.

Conclusions

There was no difference between early and later image acquisitions in terms of quality. This protocol reduces the length of the procedure for the patient. Beginning with early image acquisitions may help to overcome the artifacts that are observed at the delayed time.

Keywords

Sestamibi cadmium-zinc-telluride myocardial perfusion imaging SPECT image quality 

Abbreviations

CZT

Cadmium-zinc-telluride

LVEF

Left ventricular ejection fraction

ASNC

American Society of Nuclear Cardiology

CAD

Coronary artery disease

SPECT

Single photon emission computerized tomography

MPI

Myocardial perfusion imaging

MLEM

Maximum-likelihood expectation maximization

SD

Standard deviation

Notes

Disclosures

There is no conflict of interest to declare.

Supplementary material

12350_2016_499_MOESM1_ESM.pptx (338 kb)
Supplementary material 1 (pptx 338 kb)

References

  1. 1.
    Sharir T, Slomka PJ, Hayes SW, DiCarli MF, Ziffer JA, Martin WH, et al. Multicenter trial of high-speed versus conventional single-photon emission computed tomography imaging: Quantitative results of myocardial perfusion and left ventricular function. J Am Coll Cardiol. 2010;55:1965-74.CrossRefGoogle Scholar
  2. 2.
    Erlandsson K, Kacperski K, van Gramberg D, Hutton BF. Performance evaluation of D-SPECT: A novel SPECT system for nuclear cardiology. Phys Med Biol 2009;54:2635-49.CrossRefGoogle Scholar
  3. 3.
    Henzlova MJ, Cerqueira MD, Mahmarian JJ, Yao S-S, Quality Assurance Committee of the American Society of Nuclear Cardiology. Stress protocols and tracers. J Nucl Cardiol 2006;13:e80-90.CrossRefGoogle Scholar
  4. 4.
    Marshall RC, Leidholdt EM, Zhang DY, Barnett CA. Technetium-99 m hexakis 2-methoxy-2-isobutyl isonitrile and thallium-201 extraction, washout, and retention at varying coronary flow rates in rabbit heart. Circulation 1990;82:998-1007.CrossRefGoogle Scholar
  5. 5.
    Wackers FJ, Berman DS, Maddahi J, Watson DD, Beller GA, Strauss HW, et al. Technetium-99 m hexakis 2-methoxyisobutylisonitrile: Human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989;30:301-11.Google Scholar
  6. 6.
    Askew JW, Miller TD, Ruter RL, Jordan LG, Hodge DO, Gibbons RJ, et al. Early image acquisition using a solid-state cardiac camera for fast myocardial perfusion imaging. J Nucl Cardiol 2011;18:840-6.CrossRefGoogle Scholar
  7. 7.
    Henzlova MJ, Duvall WL. Return of dual-isotope SPECT myocardial perfusion imaging? Not so fast…. J Nucl Cardiol 2015;22:523-5.CrossRefGoogle Scholar
  8. 8.
    Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, et al. ACC/AHA 2002 guideline update for exercise testing: Summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J Am Coll Cardiol 2002;40(8):1531-40.Google Scholar
  9. 9.
    Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med 2009;50:635-43.CrossRefGoogle Scholar
  10. 10.
    Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Ben-Haim S, et al. High-speed myocardial perfusion imaging initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging 2008;1:156-63.CrossRefGoogle Scholar
  11. 11.
    Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, et al. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging 2015;42:1929-40.CrossRefGoogle Scholar
  12. 12.
    Cerqueira MD. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the cardiac imaging committee of the council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539-42.CrossRefGoogle Scholar
  13. 13.
    Giorgetti A, Rossi M, Stanislao M, Valle G, Bertolaccini P, Maneschi A, et al. Feasibility and diagnostic accuracy of a gated SPECT early-imaging protocol: A multicenter study of the Myoview Imaging Optimization Group. J Nucl Med 2007;48:1670-5.CrossRefGoogle Scholar
  14. 14.
    Berman DS, Kang X, Tamarappoo B, Wolak A, Hayes SW, Nakazato R, et al. Stress thallium-201/rest technetium-99 m sequential dual isotope high-speed myocardial perfusion imaging. JACC Cardiovasc Imaging 2009;2:273-82.CrossRefGoogle Scholar
  15. 15.
    Taillefer R, Lambert R, Bisson G, Benjamin C, Phaneuf DC. Myocardial technetium 99 m-labeled sestamibi single-photon emission computed tomographic imaging in the detection of coronary artery disease: Comparison between early (15 minutes) and delayed (60 minutes) imaging. J Nucl Cardiol 1994;1:441-8.CrossRefGoogle Scholar
  16. 16.
    Taillefer R, Dupras G, Sporn V, Rigo P, Leveille J, Boucher P, et al. Myocardial perfusion imaging with a new radiotracer, technetium-99 m-hexamibi (methoxy isobutyl isonitrile): comparison with thallium-201 imaging. Clin Nucl Med 1989;14:89-96.CrossRefGoogle Scholar
  17. 17.
    Najm YC, Maisey MN, Clarke SM, Fogelman I, Curry PV, Sowton E. Exercise myocardial perfusion scintigraphy with technetium-99 m methoxy isobutylisonitrile: A comparative study with thallium-201. Int J Cardiol 1990;26:93-102.CrossRefGoogle Scholar
  18. 18.
    Weinmann P, Faraggi M, Moretti JL, Hannequin P. Clinical validation of simultaneous dual-isotope myocardial scintigraphy. Eur J Nucl Med Mol Imaging 2003;30:25-31.CrossRefGoogle Scholar
  19. 19.
    Matsunari I, Tanishima Y, Taki J, Ono K, Nishide H, Fujino S, et al. Early and delayed technetium-99 m-tetrofosmin myocardial SPECT compared in normal volunteers. J Nucl Med 1996;37:1622-6.Google Scholar
  20. 20.
    Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99 m-tetrofosmin: myocardial perfusion imaging agent: Implications for a one-day imaging protocol. J Nucl Med 1993;34:1254-9.Google Scholar

Copyright information

© American Society of Nuclear Cardiology 2016

Authors and Affiliations

  1. 1.European Hospital Georges Pompidou, AP-HP, Nuclear MedicineUniversité Paris DescartesParisFrance

Personalised recommendations