Hepatic sinusoidal obstruction syndrome secondary to intravesical instillation of mitomycin-C
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Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening complication with high mortality rate. Even if it is more commonly described after hematopoietic stem-cell transplant, hepatic-SOS may occur following the use of certain chemotherapeutic agents. Mitomycin-C has been previously identified as a causal agent when administered intravenously at high doses. We report herein the first case of hepatic-SOS due to intravesical instillation of mitomycin-C, after a traumatic urinary catheterization with significant hematuria. Although this procedure is usually considered safe, without the systemic side effects related to intravenous administration of the drug, clinicians must be aware of its potential risks to facilitate an early diagnosis, avoid a delay in the withdrawal of the causative drug and set up an appropriate therapy as soon as possible.
KeywordsIntravesical instillation Mitomycin-C Bone marrow aplasia Hepatic sinusoidal obstruction syndrome
Sinusoidal obstruction syndrome
All the authors made substantial contributions to the conception and design of the work. Marchán-López and Pérez-Jacoiste Asín wrote the manuscript; Pérez-Jacoiste Asín and Justo-Quintas critically reviewed the manuscript; Jiménez-Almonacid provided the histological diagnosis; Arroyo-López performed and provided data of the transjugular hepatic-vein catheterization; Marchán-López and Pérez-Jacoiste Asín were in charge of medical care of the patient. All the authors approved the final draft of the manuscript to be published. All the authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy and integrity of any part of the work are appropriately investigated and resolved.
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Conflict of interest
The authors declare no conflict of interest.
All the procedures have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendements.
The family of the patient gave informed consent for the publication of the case. Confidentiality was preserved.
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