A case of cystic intraductal papillary neoplasm of the bile duct with associated adenocarcinoma
- 13 Downloads
The pathophysiology of intraductal papillary neoplasm of the bile duct (IPNB) remains unclear. We report a case of a Japanese man in his 70s with this disease, which we first diagnosed as a liver cyst. The patient was followed at our hospital for a 10-mm liver cyst and a 10-mm pancreatic cyst for 4 years. Four years later, tumor markers including CA19-9 were elevated in his blood tests. Abdominal ultrasonography showed a heterogeneous hyper-echoic mass with an anechoic area, 25 × 25 mm, in the S2 liver segment and showed posterior echo enhancement. Contrast-enhanced computed tomography showed that the tumor was gradually enhanced slightly. Magnetic resonance imaging showed a lesion of T1 low, T2 high around the cyst. Endoscopic retrograde cholangiopancreatography did not show an abnormality, including findings of the duodenal papilla. We suspected an IPNB and performed left lobe hepatectomy. The resected whitish tumor around the cyst was 25 × 23 mm. The tumor contained an intraductal papillary mass with an adjacent invasive adenocarcinoma. The papillary mass with fine vascular cores was lined by foveolar-type epithelium. Our diagnosis was IPNB with invasive adenocarcinoma. This case indicates that IPNB should be considered in the differential diagnosis of liver cysts.
KeywordsIntraductal papillary neoplasm of the bile duct Liver cyst Associated adenocarcinoma
Compliance with ethical standards
Conflict of interest
All the authors declare no conflict of interest.
All the procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent was obtained from the patient for being included in this report.
- 1.Nakanuma Y, Jang KT, Fukushima N, et al. A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage. J Hepatobiliary Pancreat Sci. 2018;25:181–7.CrossRefGoogle Scholar
- 7.Hokuto D, Nomi T, Yasuda S, et al. Long-term observation and treatment of a widespread intraductal papillary neoplasm of the bile duct extending from the intrapancreatic bile duct to the bilateral intrahepatic bile duct: a case report. Int J Surg Case Rep. 2017;38:166–71.CrossRefPubMedCentralGoogle Scholar