Breast metastasis from rectal cancer with BRAF V600E mutation: a case report with a review of the literature

  • Hiroko HasegawaEmail author
  • Yoko Nagata
  • Yuko Sakakibara
  • Masakazu Miyake
  • Kiyoshi Mori
  • Norikazu Masuda
  • Masayuki Mano
  • Shoichi Nakazuru
  • Hisashi Ishida
  • Eiji Mita
Case Report


Metastasis of rectal cancer to the breast is an extremely rare clinical event. We report the case of a 67-year-old woman with a metastatic breast tumor derived from a BRAF V600E mutant rectal carcinoma that was diagnosed and resected curatively 1 year previously. Computed tomography showed a left breast mass and multiple lung nodules suspected to be indicative of recurrent rectal cancer. The ultrasonography examination demonstrated a 10 × 10-mm hypoechoic solid lesion in the left breast with an elevation in the serum carcinoembryonic antigen level and serum carbohydrate antigen 19-9 level. Core needle biopsy was performed, and histopathologic examination showed Cytokeratin 20 and CDX-2 positivity, compatible with rectal cancer. To our knowledge, this is the first case of a metastatic breast tumor arising from rectal carcinoma with BRAF mutation. Although breast metastasis is very rare event, the possibility of breast metastasis from extra mammary sites should be considered when the breast tumor is found in cancer treatment.


Breast metastasis Rectal cancer BRAF V600E mutation 




Compliance with ethical standards

Conflict of interest

The authors do not have any financial relationships with a biotechnology manufacturer, a pharmaceutical company, or other commercial entity that has any interest in the subject matter connected with our case report.

Human rights

All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration.

Informed consent

Informed consent was obtained from the patient to be included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Hiroko Hasegawa
    • 1
    Email author
  • Yoko Nagata
    • 2
  • Yuko Sakakibara
    • 1
  • Masakazu Miyake
    • 2
  • Kiyoshi Mori
    • 3
  • Norikazu Masuda
    • 2
  • Masayuki Mano
    • 3
  • Shoichi Nakazuru
    • 1
  • Hisashi Ishida
    • 1
  • Eiji Mita
    • 1
  1. 1.Department of Gastroenterology and HepatologyNational Hospital Organization, Osaka National HospitalOsakaJapan
  2. 2.Department of SurgeryNational Hospital Organization, Osaka National HospitalOsakaJapan
  3. 3.Department of PathologyNational Hospital Organization, Osaka National HospitalOsakaJapan

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