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Association between Crohn’s disease and AarF domain-containing kinase 4 glomerulopathy

  • Toshihiko KakiuchiEmail author
  • Yasufumi Ohtsuka
  • Tadashi Sato
  • Aiko Nakayama
  • Kumiko Jinnouchi
  • Masafumi Oka
  • Muneaki Matsuo
Case Report
  • 24 Downloads

Abstract

Coenzyme Q10 deficiency causing gastrointestinal symptoms has not been reported. At least 15 genes are involved in CoQ10 biosynthesis, and one of the genes is AarF domain-containing kinase 4 (ADCK4). This case report first showed a patient who presented with Crohn’s disease (CD) combined with ADCK4 glomerulopathy (ADCK4-GN). After approximately 2 years of infliximab treatment for CD, this patient has remained in clinical remission with no adverse effects. Moreover, two important findings were obtained: first, individuals with ADCK4-GN may present with complications, such as CD, which is a gastrointestinal disease, and infliximab may be effective for CD associated with ADCK4-GN. Second, infliximab may also be effective and safe for individuals with CD who are undergoing peritoneal dialysis. Thus, the results of the present study may be used in managing patients with such condition, and as a result, better clinical outcomes will be obtained.

Keywords

AarF domain-containing kinase 4 glomerulopathy Crohn’s disease Infliximab Peritoneal dialysis 

Notes

Acknowledgements

The authors would like to thank the patient’s family for consenting and allowing them to write and publish this case report.

Author contributions

As the lead author, TK was involved with all stage of patient management and wrote the manuscript. YO, TS, AN, KJ and MO performed the treatment. MM collaborated as the reviewer. All authors read and approved the final manuscript.

Funding

No financial supports.

Compliance with ethical standards

Conflict of interest

Kakiuchi T, Ohtsuka Y, Sato T, Nakayama A, Jinnouchi K, Oka M and Matsuo M declare that they no conflict of interest.

Human/animal rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  1. 1.Department of Pediatrics, Faculty of MedicineSaga UniversitySaga-shiJapan
  2. 2.Department of PediatricsUreshino Medical CenterUreshino-shiJapan

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