Association between Crohn’s disease and AarF domain-containing kinase 4 glomerulopathy
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Coenzyme Q10 deficiency causing gastrointestinal symptoms has not been reported. At least 15 genes are involved in CoQ10 biosynthesis, and one of the genes is AarF domain-containing kinase 4 (ADCK4). This case report first showed a patient who presented with Crohn’s disease (CD) combined with ADCK4 glomerulopathy (ADCK4-GN). After approximately 2 years of infliximab treatment for CD, this patient has remained in clinical remission with no adverse effects. Moreover, two important findings were obtained: first, individuals with ADCK4-GN may present with complications, such as CD, which is a gastrointestinal disease, and infliximab may be effective for CD associated with ADCK4-GN. Second, infliximab may also be effective and safe for individuals with CD who are undergoing peritoneal dialysis. Thus, the results of the present study may be used in managing patients with such condition, and as a result, better clinical outcomes will be obtained.
KeywordsAarF domain-containing kinase 4 glomerulopathy Crohn’s disease Infliximab Peritoneal dialysis
The authors would like to thank the patient’s family for consenting and allowing them to write and publish this case report.
As the lead author, TK was involved with all stage of patient management and wrote the manuscript. YO, TS, AN, KJ and MO performed the treatment. MM collaborated as the reviewer. All authors read and approved the final manuscript.
No financial supports.
Compliance with ethical standards
Conflict of interest
Kakiuchi T, Ohtsuka Y, Sato T, Nakayama A, Jinnouchi K, Oka M and Matsuo M declare that they no conflict of interest.
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent was obtained from all patients for being included in the study.
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