Clinical Journal of Gastroenterology

, Volume 12, Issue 1, pp 52–56 | Cite as

A resected case of gallbladder metastasis with symptoms of acute cholecystitis in multiple metastatic ductal carcinoma of the breast

  • Takeshi UradeEmail author
  • Shigeteru Oka
  • Shinya Iimori
  • Mariko Man-i
  • Tomoki Abe
  • Hidehiro Sawa
  • Yoshiteru Iwatani
  • Yukiko Morinaga
  • Daisuke Kuroda
Case Report


Gallbladder metastasis from breast cancer, especially from ductal carcinoma, is rare. Herein, we report a rare case of gallbladder metastasis from ductal carcinoma of the breast that was diagnosed after laparoscopic cholecystectomy (LC) for acute cholecystitis. A 78-year-old woman presented with right upper abdominal tenderness and positive Murphy’s sign during chemotherapy for advanced multiple metastases of the breast cancer. Abdominal ultrasonography and computed tomography showed a slightly thickened gallbladder wall and two calculi. After a diagnosis of acute calculous cholecystitis was established, LC was performed. Pathological examination revealed poorly differentiated adenocarcinoma infiltrating the submucosal and subserosal layer over the entire gallbladder, and a lymph node metastasis in the gallbladder neck. Immunohistochemical examination revealed that the tumor cells tested positive for estrogen receptor and negative for progesterone receptor, which was consistent with primary breast cancer. The patient was uneventfully discharged without abdominal pain 7 days later. Although she subsequently underwent several chemotherapies, she died 16 months later. In conclusion, gallbladder metastasis should be considered in patients with multiple metastatic breast cancer who present with signs or symptoms of cholecystitis. Moreover, LC should be considered to relieve the symptoms of cholecystitis for improved prognosis, even in a patient with multiple metastases.


Breast cancer Ductal carcinoma Gallbladder metastasis Laparoscopic cholecystectomy 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  1. 1.Department of Surgery and Digestive SurgeryKita-Harima Medical CenterOnoJapan
  2. 2.Department of Diagnostic PathologyKita-Harima Medical CenterOnoJapan

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