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Primary leiomyosarcoma of the colon

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Abstract

Primary leiomyosarcomas of the gastrointestinal (GI) tract are extremely rare and highly aggressive neoplasms, and only a small number of true cases have been reported since the concept of GI stromal tumors was established. Here, we report a case of a primary leiomyosarcoma of the transverse colon. A 46-year-old Japanese male with a large mass in the right upper abdomen was admitted to our hospital. Computed tomography and magnetic resonance imaging revealed long segments of wall thickening of the transverse colon with large consecutive tumors measuring 12 cm in diameter. A projecting irregular mass with marked mucosal necrosis was found on colonoscopy. Pathological examination revealed a spindle cell tumor growing circumferentially and transmurally to replace the muscularis propria in the transverse colon. The spindle cells were positive for smooth muscle actin, and negative for KIT, CD34, DOG-1, and S-100 protein. The patient has shown repeat recurrence in spite of sufficient surgical excision being promptly performed.

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Authors and Affiliations

  1. Department of Gastroenterology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai, 590-0132, Japan

    Masashi Kono, Naoko Tsuji, Nobuto Ozaki, Nozomu Matsumoto, Takehisa Takaba, Naoki Okumura, Masanori Kawasaki, Takafumi Tomita, Yasuko Umehara & Satoko Taniike

  2. Department of Surgery, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai, 590-0132, Japan

    Shigeru Hatabe & Sadao Funai

  3. Department of Radiology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai, 590-0132, Japan

    Yukihhiko Ono

  4. Department of Pathology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai, 590-0132, Japan

    Ken Ochiai & Shunji Maekura

  5. Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377-2 Onohigashi, Osaka-Sayama, 589-8511, Japan

    Masatoshi Kudo

Authors
  1. Masashi Kono
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  2. Naoko Tsuji
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  3. Nobuto Ozaki
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  4. Nozomu Matsumoto
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  5. Takehisa Takaba
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  6. Naoki Okumura
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  7. Masanori Kawasaki
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  8. Takafumi Tomita
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  9. Yasuko Umehara
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  10. Satoko Taniike
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  11. Shigeru Hatabe
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  12. Sadao Funai
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  13. Yukihhiko Ono
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  14. Ken Ochiai
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  15. Shunji Maekura
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  16. Masatoshi Kudo
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Corresponding author

Correspondence to Naoko Tsuji.

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Conflict of Interest

Masatoshi Kudo received honoraria for giving lectures for Banyu Yakuhin and Eisai.

Human/Animal Rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

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Informed consent was obtained from the patient to be included in this report.

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Cite this article

Kono, M., Tsuji, N., Ozaki, N. et al. Primary leiomyosarcoma of the colon. Clin J Gastroenterol 8, 217–222 (2015). https://doi.org/10.1007/s12328-015-0584-9

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  • DOI: https://doi.org/10.1007/s12328-015-0584-9

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