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Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?

  • Jan Cendelin
  • Annalisa Buffo
  • Hirokazu Hirai
  • Lorenzo Magrassi
  • Hiroshi Mitoma
  • Rachel Sherrard
  • Frantisek Vozeh
  • Mario MantoEmail author
Review

Abstract

Restoration of damaged central nervous system structures, functional recovery, and prevention of neuronal loss during neurodegenerative diseases are major objectives in cerebellar research. The highly organized anatomical structure of the cerebellum with numerous inputs/outputs, the complexity of cerebellar functions, and the large spectrum of cerebellar ataxias render therapies of cerebellar disorders highly challenging. There are currently several therapeutic approaches including motor rehabilitation, neuroprotective drugs, non-invasive cerebellar stimulation, molecularly based therapy targeting pathogenesis of the disease, and neurotransplantation. We discuss the goals and possible beneficial mechanisms of transplantation therapy for cerebellar damage and its limitations and factors determining outcome.

Keywords

Ataxias Cerebellum Cerebellar reserve Neurotransplantation Stem cells 

Notes

Authors’ Contribution

The authors were responsible for drafting specific sections, and all of them revised and contributed to the entire article.

Funding Information

This work was supported by the National Sustainability Program I (NPU I) (no. LO1503) provided by the Ministry of Education, Youth and Sports of the Czech Republic; by the Charles University Research Fund (project number Q39), MEXT KAKENHI (grant number 15H04254); and by the Gunma University Initiative for Advanced Research (GIAR), Funds of the University of Turin and of the Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) project “Dipartimenti di Eccellenza 2018–2022” to the Department of Neuroscience, University of Turin.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jan Cendelin
    • 1
    • 2
  • Annalisa Buffo
    • 3
    • 4
  • Hirokazu Hirai
    • 5
  • Lorenzo Magrassi
    • 6
    • 7
  • Hiroshi Mitoma
    • 8
  • Rachel Sherrard
    • 9
  • Frantisek Vozeh
    • 1
    • 2
  • Mario Manto
    • 10
    • 11
    Email author
  1. 1.Department of Pathophysiology, Faculty of Medicine in PilsenCharles UniversityPlzenCzech Republic
  2. 2.Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in PilsenCharles UniversityPlzenCzech Republic
  3. 3.Department of Neuroscience Rita Levi-MontalciniUniversity of TurinTurinItaly
  4. 4.Neuroscience Institute Cavalieri OttolenghiTurinItaly
  5. 5.Department of Neurophysiology and Neural RepairGunma University Graduate School of MedicineMaebashiJapan
  6. 6.Neurosurgery, Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Fondazione IRCCS Policlinico S. MatteoUniversità degli Studi di PaviaPaviaItaly
  7. 7.Istituto di Genetica Molecolare – CNRPaviaItaly
  8. 8.Medical Education Promotion CenterTokyo Medical UniversityTokyoJapan
  9. 9.IBPS, UMR8256 Biological Adaptation and AgeingSorbonne Université and CNRSParisFrance
  10. 10.Department of NeurologyCHU-CharleroiCharleroiBelgium
  11. 11.Service des NeurosciencesUniversité de MonsMonsBelgium

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