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The Cerebellum

, Volume 18, Issue 1, pp 85–90 | Cite as

Olfactory Function in SCA10

  • Mariana MoscovichEmail author
  • Renato Puppi Munhoz
  • Adriana Moro
  • Salmo Raskin
  • Karen McFarland
  • Tetsuo Ashizawa
  • Helio A. G. Teive
  • Laura Silveira-Moriyama
Original Paper

Abstract

Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson’s, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson’s disease (PD)) and 44 healthy controls using the Sniffin’ Sticks (SS16) test. Mean SS16 score was 11.9 ± 2.9 for the SCA10 group, 12.3 ± 1.9 for the SCA3 group, 6.6 ± 2.8 for the PD group, and 12.1 ± 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p < 0.001) when adjusted for age, gender, and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups or number of repeat expansions. SS16 and Mini Mental State Examination scores were correlated in the three groups: SCA10 group (r = 0.59, p = 0.001), SCA3 group (r = 0.50, p = 0.005), and control group (r = 0.40, p = 0.007). We found no significant olfactory deficits in SCA10 in this large series.

Keywords

Cerebellar degeneration Movement disorders Olfaction Spinocerebellar ataxia Smell 

Notes

Author Contributions

M Moscovich conceptualized the study, analyzed the data in the study, drafted the manuscript, and revised the manuscript. R P Munhoz drafted the manuscript and revised the manuscript. H A Teive designed the study and revised the manuscript. S Raskin revised the manuscript. A Moro revised the manuscript. K McFarland revised the manuscript. T Ashizawa revised the manuscript. L Silveira-Moriyama designed the study, interpreted the data in the study, analyzed the data in the study, drafted the manuscript, and revised the manuscript.

Compliance with Ethical Standards

Informed consent was obtained from all participants, and the protocol was approved by the local (UFPR) ethics committee.

Conflict of Interest

Dr. Moscovich, Dr. Munhoz, Dr. Moro, Dr. Raskin, and Dr. McFarland report no disclosure. Dr. Ashizawa is funded by NIH grant NS083564. Teive received personal compensation for educational activities with Allergan, Ipsen, Teva, and UCB and serves as an editor-in-chief of Arquivos de Neuro-Psiquiatria and editorial board member of Movement Disorder Clinical Practice, the Journal of Neurology Research, Parkinson’s Disease, Current Neurology and Neuroscience Reports, and Arquivos de Neuropsiquiatria. Dr. Laura Silveira-Moriyama received travel grants from Teva and supervised scholarships from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Mariana Moscovich
    • 1
    • 2
    Email author
  • Renato Puppi Munhoz
    • 3
  • Adriana Moro
    • 1
  • Salmo Raskin
    • 4
  • Karen McFarland
    • 2
  • Tetsuo Ashizawa
    • 5
  • Helio A. G. Teive
    • 1
  • Laura Silveira-Moriyama
    • 6
    • 7
    • 8
    • 9
  1. 1.Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de ClínicasUniversidade Federal do ParanáCuritibaBrazil
  2. 2.Department of Neurology, UKSH, Campus KielChristian-Albrechts-UniversityKielGermany
  3. 3.Movement Disorders Centre, Toronto Western HospitalUniversity of TorontoTorontoCanada
  4. 4.Group for Advanced Molecular Investigation (NIMA), School of Health and BiosciencesPontifícia Universidade Católica do Paraná (PUCPR)CuritibaBrazil
  5. 5.Department of Neurology, Houston MethodistWeill Cornell Medical CollegeHoustonUSA
  6. 6.Postgraduate Program in MedicineUniversidade Nove de Julho, UninoveSão PauloBrazil
  7. 7.Reta Lila Weston Institute of Neurological StudiesUCL Institute of NeurologyLondonUK
  8. 8.Departamento de NeurologiaUniversidade Estadual de Campinas, UNICAMPCampinasBrazil
  9. 9.Departamento de NeurologiaUniversidade de São Paulo, USPSão PauloBrazil

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