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Primary ovarian diffuse large B-cell lymphoma preceded by autoimmune hemolytic anemia

  • Satoshi IchikawaEmail author
  • Asami Sasaoka
  • Noriko Fukuhara
  • Yoko Okitsu
  • Yasushi Onishi
  • Ryo Ichinohasama
  • Hideo Harigae
Case Report
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Abstract

A 62-year-old woman was diagnosed with autoimmune hemolytic anemia (AIHA), with cytology- and culture-negative pleural effusion. AIHA did not improve with steroid therapy. Computerized tomography (CT) detected a left ovarian tumor, which was resected surgically, and AIHA improved temporarily. Pathological examination yielded a diagnosis of diffuse large B-cell lymphoma (DLBCL). Positron emission tomography with CT suggested systemic infiltration of lymphoma. Rituximab-containing chemotherapy (R-CHOP regimen) yielded rapid decreases in lymphoma lesions and pleural effusion with improvement of AIHA. After six courses of R-CHOP, complete response (CR) was confirmed and AIHA remitted completely. Two months after confirmation of CR, however, lymphoma and AIHA relapsed simultaneously. To our knowledge, this is the first case report describing ovarian DLBCL preceded by AIHA.

Keywords

Autoimmune hemolytic anemia Diffuse large B-cell lymphoma Primary ovarian lymphoma 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

References

  1. 1.
    Packman CH (2015) The clinical pictures of autoimmune hemolytic anemia. Transfus Med Hemother 42:317–324CrossRefGoogle Scholar
  2. 2.
    Valent P, Lechner K (2008) Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review. Wien Klin Wochenschr 120:136–151CrossRefGoogle Scholar
  3. 3.
    Sallah S, Sigounas G, Vos P, Wan JY, Nguyen NP (2000) Autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma: characteristics and significance. Ann Oncol 11:1571–1577CrossRefGoogle Scholar
  4. 4.
    Hauswirth AW, Skrabs C, Schutzinger C et al (2007) Autoimmune hemolytic anemias, Evans' syndromes, and pure red cell aplasia in non-Hodgkin lymphomas. Leuk Lymphoma 48:1139–1149CrossRefGoogle Scholar
  5. 5.
    Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, Holcomb K (2017) Primary lymphoma of the female genital tract: an analysis of 697 cases. Gynecol Oncol 145:305–309CrossRefGoogle Scholar
  6. 6.
    Vang R, Medeiros LJ, Fuller GN, Sarris AH, Deavers M (2001) Non-Hodgkin's lymphoma involving the gynecologic tract: a review of 88 cases. Adv Anat Pathol 8:200–217CrossRefGoogle Scholar
  7. 7.
    Zhao XY, Hong XN, Cao JN, Leaw SJ, Guo Y, Li ZT, Chang JH (2011) Clinical features and treatment outcomes of 14 cases of primary ovarian non-Hodgkin's lymphoma: a single-center experience. Med Oncol 28:1559–1564CrossRefGoogle Scholar
  8. 8.
    Cao XX, Li J, Zhang W, Duan MH, Shen T, Zhou DB (2014) Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse. Ann Hematol 93:1001–1005CrossRefGoogle Scholar
  9. 9.
    Nobuoka A, Sakamaki S, Kogawa K, Fujikawa K, Takahashi M, Hirayama Y, Takayanagi N, Ikeda H, Sekiguchi S, Niitsu Y (1999) A case of malignant lymphoma producing autoantibody against platelet glycoprotein Ib. Int J Hematol 70:200–206PubMedGoogle Scholar
  10. 10.
    Bhartiya R, Kumari N, Mallik M, Singh RV (2016) Primary non-Hodgkin's lymphoma of the ovary - a case report. J Clin Diagn Res 10:ED10–ED11PubMedPubMedCentralGoogle Scholar
  11. 11.
    Islimye Taskin M, Gokgozoglu L, Kandemir B (2013) Primary ovarian large B-cell lymphoma. Case Rep Obstet Gynecol 2013:493836PubMedPubMedCentralGoogle Scholar
  12. 12.
    Takei T, Uchiyama M (2013) Primary ovarian non-Hodgkin's lymphoma. BMJ Case Rep 2013Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Hematology and RheumatologyTohoku University HospitalSendaiJapan
  2. 2.Department of HematopathologyTohoku University HospitalSendaiJapan

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