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Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study

  • Hye-Ra Jung
  • Jooryung Huh
  • Young-Hyeh Ko
  • Yoon Kyung Jeon
  • Sun Och Yoon
  • Se Hoon Kim
  • Woo Ick Yang
  • Geongsin Park
  • Jo Heon Kim
  • Jin Ho Paik
  • Jae Ho Han
  • Hee Jung Cha
  • Kyu Yun Jang
  • Bong-Kyung Shin
  • Young-A Kim
  • Ji Eun Kim
  • Yoo Duk Choi
  • Min Gyoung Park
  • Hee Kyung Kim
  • Suk Jin Choi
  • Bo Mi Kim
  • Jong Sil Lee
  • Hee-Kyung Chang
  • Ji-Young Choe
  • Soo Kee Min
  • Dae Woon Eom
  • Min-Sun Cho
  • Seol Bong Yoo
  • Wook Youn Kim
  • Hyekyung Lee
  • In Ho Choi
  • Yo Sep Chong
  • Hyang Im Lee
  • Ho Jung Lee
  • Seung-Sook Lee
  • Hyun-Jung KimEmail author
Original Article
  • 23 Downloads

Abstract

To determine the relative frequency and change of malignant lymphoma in Korea according to the 4th World Health Organization (WHO) classification and compare with previous reports. Between 2015 and 2016, 7737 new patients with malignant lymphoma were enrolled from 31 institutes, with their clinicopathologic information obtained, and evaluated for the relative frequency of lymphoma subtypes. The relative frequency of non-Hodgkin lymphoma (NHL) was 94.8%, and that of Hodgkin lymphoma (HL) was 5.2%. B cell lymphomas accounted for 83.1% of all NHLs; T/natural killer (NK) cell lymphomas, 16.4%; and immunodeficiency-associated lymphoproliferative disorders, 0.5%. The most common NHL subtypes were diffuse large B cell (41.5%), extranodal marginal zone (MALT, 19.8%), follicular (7.5%), NK/ T cell (4.2%), and peripheral T cell lymphomas, not otherwise specific (PTCL, NOS, 3.4%). Nodular sclerosis was the predominant HL subtype (48.5%), followed by mixed cellularity (28.7%), lymphocyte-rich (6.8%), lymphocyte-depleted (1.5%), lymphocyte-predominant (2.8%), and unclassified HL (11.8%). Compared with a previous report, increased B cell lymphomas (77.6–83.1%) and slightly decreased NK/T cell lymphomas and PTCL were observed. The incidence of follicular lymphoma increased by more than 2.5-fold (2.9–7.5%). Incidence rates of newly diagnosed lymphomas were lower for HL and higher for extranodal NHL, MALT, and nasal type NK/T cell lymphomas in Korea than those in Western countries. A slight increase in the relative frequency of B cell lymphoma and a prominent increase in follicular lymphoma may be attributed to refined diagnostic criteria and Westernized disease patterns.

Keywords

Incidence Malignant lymphoma WHO classification Korea 

Notes

Acknowledgments

This work was supported by the 2017 study group supporting program of the Korean Society of Pathologists.

Compliance with ethical standards

All procedures were approved by the respective institutional review boards of participating institutions.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hye-Ra Jung
    • 1
  • Jooryung Huh
    • 2
  • Young-Hyeh Ko
    • 3
  • Yoon Kyung Jeon
    • 4
  • Sun Och Yoon
    • 5
  • Se Hoon Kim
    • 5
  • Woo Ick Yang
    • 5
  • Geongsin Park
    • 6
  • Jo Heon Kim
    • 7
  • Jin Ho Paik
    • 8
  • Jae Ho Han
    • 9
  • Hee Jung Cha
    • 10
  • Kyu Yun Jang
    • 11
  • Bong-Kyung Shin
    • 12
  • Young-A Kim
    • 13
  • Ji Eun Kim
    • 13
  • Yoo Duk Choi
    • 14
  • Min Gyoung Park
    • 15
  • Hee Kyung Kim
    • 16
  • Suk Jin Choi
    • 17
  • Bo Mi Kim
    • 18
  • Jong Sil Lee
    • 19
  • Hee-Kyung Chang
    • 20
  • Ji-Young Choe
    • 21
  • Soo Kee Min
    • 21
  • Dae Woon Eom
    • 22
  • Min-Sun Cho
    • 23
  • Seol Bong Yoo
    • 24
  • Wook Youn Kim
    • 25
  • Hyekyung Lee
    • 26
  • In Ho Choi
    • 27
  • Yo Sep Chong
    • 28
  • Hyang Im Lee
    • 29
  • Ho Jung Lee
    • 30
  • Seung-Sook Lee
    • 31
  • Hyun-Jung Kim
    • 32
    Email author
  1. 1.Department of PathologyKeimyung UniversityDaeguSouth Korea
  2. 2.Department of PathologyAsan Medical CenterSeoulSouth Korea
  3. 3.Department of PathologySamsung Medical Center SeoulSeoulSouth Korea
  4. 4.Department of PathologySeoul National UniversitySeoulSouth Korea
  5. 5.Department of PathologyYonsei University Severance HospitalSeoulSouth Korea
  6. 6.Department of PathologySeoul St. Mary’s Hospital, The Catholic UniversitySeoulSouth Korea
  7. 7.Department of PathologyChonnam University Hwasun HospitalHwasunSouth Korea
  8. 8.Department of PathologySeoul University Bungdang HospitalSeongnamSouth Korea
  9. 9.Department of PathologyAjou UniversitySuwonSouth Korea
  10. 10.Department of PathologyUlsan UniversityUlsanSouth Korea
  11. 11.Department of PathologyChonbuk UniversityJeonjuSouth Korea
  12. 12.Department of PathologyKorea University Guro HospitalSeoulSouth Korea
  13. 13.Department of PathologySeoul National University Boramae HospitalSeoulSouth Korea
  14. 14.Department of PathologyChonnam UniversityGwang-juSouth Korea
  15. 15.Department of PathologyDong-A Medical CenterBusanSouth Korea
  16. 16.Department of PathologySoonchunhyang University Bucheon HospitalBucheonSouth Korea
  17. 17.Department of PathologyInha UniversityIncheonSouth Korea
  18. 18.Department of PathologyInje University Haeundae Paik HospitalBusanSouth Korea
  19. 19.Department of PathologyGyeongsang UniversityBusanSouth Korea
  20. 20.Department of PathologyKosin UniversityBusanSouth Korea
  21. 21.Department of PathologyHallym University Sacred Heart HospitalAnyangSouth Korea
  22. 22.Department of PathologyGangneung Asan HospitalGangneungSouth Korea
  23. 23.Department of PathologyEwha Woman’s UniversitySeoulSouth Korea
  24. 24.Department of PathologyJeonju Presbyterian Medical CenterJeonjuSouth Korea
  25. 25.Department of PathologyKonkuk UniversitySeoulSouth Korea
  26. 26.Department of PathologyEulji University HospitalDaejeonSouth Korea
  27. 27.Department of PathologySoonchunhyang University Seoul HospitalSeoulSouth Korea
  28. 28.Department of PathologyYeouido St. Mary’s Hospital, The Catholic UniversitySeoulSouth Korea
  29. 29.Department of PathologyGyeongsang University Changwon HospitalChangwonSouth Korea
  30. 30.Department of PathologyNowon Eulji University HospitalSeoulSouth Korea
  31. 31.Department of PathologyKorea Cancer Center HospitalSeoulSouth Korea
  32. 32.Department of PathologyInje University Sanggye Paik HospitalSeoulRepublic of Korea

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