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Journal of Hematopathology

, Volume 12, Issue 3, pp 149–156 | Cite as

Post-transplant lymphoproliferative disorder manifesting as lymphomatoid granulomatosis: report of two cases and review of the literature highlighting current challenges in pathologic classification

  • Jonathan J. Douds
  • Joyce E. Johnson
  • Ty W. Abel
  • John P. Greer
  • Mary Ann Thompson
  • Alexandra E. KovachEmail author
Case Report
  • 14 Downloads

Abstract

Classification of viral- and immunodeficiency-associated lymphoproliferative disorders continues to evolve. Entities in these categories recognized in the 2016 revision of the World Health Organization Classification of Lymphoid Neoplasms show considerable morphologic overlap, and it is unclear whether the current classification conceptualizes the scenarios in which these lesions arise and how they might be best managed. Here, we report two cases of lymphoproliferative disorders meeting histologic criteria for lymphomatoid granulomatosis that arose following solid organ transplant. In reviewing the clinicopathologic features of these examples and those of similar cases in the literature, we highlight challenges in current classification and opportunities for their refinement.

Keywords

Lymphomatoid granulomatosis Post-transplant lymphoproliferative disorder EBV EBER Lymphoma 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Jonathan J. Douds
    • 1
  • Joyce E. Johnson
    • 2
  • Ty W. Abel
    • 1
    • 3
  • John P. Greer
    • 4
  • Mary Ann Thompson
    • 1
  • Alexandra E. Kovach
    • 1
    • 3
    Email author
  1. 1.Division of HematopathologyDepartment of Pathology,Microbiology & Immunology; Vanderbilt University Medical CenterNashvilleUSA
  2. 2.Division of Pulmonary PathologyDepartment of Pathology, Microbiology & Immunology; Vanderbilt University Medical CenterNashvilleUSA
  3. 3.Division of NeuropathologyDepartment of Pathology, Microbiology & immunology; Vanderbilt University Medical CenterNashvilleUSA
  4. 4.Division of Hematology/OncologyDepartment of Medicine; Vanderbilt University Medical CenterNashvilleUSA

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