Determining the frequency of iron overload at diagnosis in de novo acute myeloid leukemia patients with multilineage dysplasia or myelodysplasia-related changes: a case control study

  • Boran YavuzEmail author
  • Seda Aydın
  • Süreyya Bozkurt
  • Ayşegül Üner
  • Yahya Büyükaşık
Original Article


Acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a new disease category, which was defined as a separate entity in the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. While pre-treatment iron overload in patients with myelodysplastic syndrome has been previously studied, its relationship with AML-MRC has not been studied. We aimed to investigate the relationship between serum iron tests compatible with iron overload and the diagnosis of multilineage dysplasia (MLD) and AML with myelodysplasia-related changes (AML-MRC) in AML patients diagnosed at Hacettepe University Adult Hospital between January 2002 and September 2017. Ninety-three patients who met the criteria were enrolled. Bone marrow aspirate of each patient was re-examined, and dysplasia was investigated; other data were examined from patient’s records. The iron overload status at diagnosis and transferrin saturation (TS) values were compared between the groups with and without MLD and those with and without AML-MRC. When iron overload was defined as TS ≥ 58% and ferritin ≥ 500 ng/mL, iron overload was observed in 10 (37%) patients with MLD and in 4 (13%) without MLD. The difference is almost statistically significant (p = 0.053). The mean TS value and frequency of iron overload were higher in AML-MRC patients than in non-AML-MRC patients (p < 0.05 for both). A mild positive significant correlation was observed between the dysplasia severity score and TS (r = 0.317, p = 0.032). In patients with AML-MLD and AML-MRC, iron overload occurred regardless of the transfusion status at the time of diagnosis. Morphologic severity of dysplasia may be correlated with higher TS values at the time of diagnosis.


Acute myeloid leukemia AML with myelodysplasia-related changes Iron overload Multilineage dysplasia Transferrin saturation 



While there was not substantial funding needed for this research, it was done using the research infrastructure of Hacettepe University and Ankara University.

Compliance with ethical standards

This study was approved by the Ethics Committee for Non-Interventional Clinical Investigations of Hacettepe University on December 27, 2017 (decision number GO 17/794-28).

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine, School of MedicineHacettepe UniversityAnkaraTurkey
  2. 2.Department of Internal Medicine, Section of Hematology, School of MedicineHacettepe UniversityAnkaraTurkey
  3. 3.Department of Medical Biology, School of Medicineİstinye UniversityIstanbulTurkey
  4. 4.Department of Pathology, School of MedicineHacettepe UniversityAnkaraTurkey

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