Journal of Hematopathology

, Volume 11, Issue 4, pp 99–105 | Cite as

Distribution of lymphomas in Mexico: a multicenter descriptive study

  • Adrian Carballo-ZarateEmail author
  • Alejandro Garcia-Horton
  • Lizbeth Palma-Berre
  • Patricia Ramos-Salazar
  • Rogelio Sanchez-Verin-Lucio
  • Jorge Valenzuela-Tamariz
  • Lourdes Molinar-Horcasitas
  • Alejandro Lazo-Langner
  • Alejandra Zarate-Osorno
Original Article


Epidemiology of lymphoma is not well described in Mexico. We determined the frequencies and subtypes of the main non-Hodgkin’s and Hodgkin’s lymphomas in the Mexican population. Files for tissue samples for lymphomas stored in five different hospitals in Mexico City were retrieved for re-analysis and further immunostaining. The most common mature B cell, T cell/NK cell, Hodgkin’s, and precursor lymphoid neoplasms were identified according to the 2008 WHO classification of tumors. All stains were performed in the same laboratory and interpreted by three pathologists. Five thousand seven hundred seventy-two neoplasms were included. Of these, 4213 were mature B cell neoplasms (73%; 95% CI 71.83–74.12), 888 Hodgkin’s lymphomas (HLs) (15%; 95% CI 14.48–16.34), 496 mature T cell/NK neoplasms (9%; 95% CI 7.89–9.34), and 175 precursor lymphoid neoplasms (3%; 95% CI 2.62–3.5). Neoplasms had an even distribution between sexes. Main mature B cell lymphomas were diffuse large B cell lymphoma (DLBCL) (56%; 95% CI 54.39–57.39) and follicular lymphoma (FL) (20%; 95% CI 18.92–21.34). Hodgkin’s lymphomas were also classified into five main subtypes, with nodular sclerosis (47%; 95% CI 44.14–50.7) and mixed cellularity (38%; 95% CI 34.49–40.85) being the most common. The most common mature T cell/NK neoplasm was peripheral T cell lymphoma NOS/anaplastic large cell lymphoma ALK negative (44%; 95% CI 39.85–48.84). This is the first descriptive study in Mexico with a large sample of lymphomas classified according to the 2008 WHO classification. The results obtained are in keeping with the numbers described in other populations.


Hodgkin’s lymphoma Non-Hodgkin’s lymphoma T cell 



AC-Z, AG-H, LP-B, PR-S, RS-V-L, JV-T, and LM-H abstracted the data. AG-H and AC-Z analyzed the data. AZ-O and AL-L conceived the study. AG-H, AC-Z, and AL-L drafted the manuscript. All authors reviewed and approved the final version. All persons who contributed significantly to this work have been acknowledged.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Adrian Carballo-Zarate
    • 1
    • 2
    Email author
  • Alejandro Garcia-Horton
    • 3
  • Lizbeth Palma-Berre
    • 4
  • Patricia Ramos-Salazar
    • 5
  • Rogelio Sanchez-Verin-Lucio
    • 1
    • 2
  • Jorge Valenzuela-Tamariz
    • 6
  • Lourdes Molinar-Horcasitas
    • 7
  • Alejandro Lazo-Langner
    • 3
    • 8
  • Alejandra Zarate-Osorno
    • 1
    • 2
  1. 1.Department of PathologyHospital Español de MéxicoMexico CityMexico
  2. 2.Laboratory of Pathology, Immunohistochemistry and Cytopathology, SCMexico CityMexico
  3. 3.Department of Medicine, Division of HematologyWestern UniversityLondonCanada
  4. 4.Department of OncogenomicsNational Cancer InstituteMexico CityMexico
  5. 5.Department of PathologyNational Medical Center “La Raza”Mexico CityMexico
  6. 6.Department of PathologyAngeles del Pedregal HospitalMexico CityMexico
  7. 7.Department of PathologyAngeles de Las Lomas HospitalHuixquilucanMexico
  8. 8.Department of Epidemiology and BiostatisticsWestern UniversityLondonCanada

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