Journal of Hematopathology

, Volume 11, Issue 4, pp 107–113 | Cite as

Post-transplant CD4+ non-cytotoxic γδ T cell lymphoma with lymph node involvement

  • Kristin H. KarnerEmail author
  • Madhu P. Menon
  • Kedar V. Inamdar
  • John L. Carey
Case Report


Gamma delta T cells represent a minor subset of the normal lymphocyte component of the human immune system, largely inhabiting mucosal surfaces. Gamma delta T cell lymphomas (γδ TCLs) are thought to be derived from these cells and are rare, extremely aggressive lymphomas that typically exhibit a cytotoxic phenotype and often present in extranodal sites, most commonly as cutaneous or hepatosplenic subtypes. The immunophenotype usually lacks both CD4 and CD8 expression, but occasional cases express CD8. CD4 expression in γδ TCLs is exceedingly rare. The few reported cases tend to show a non-cytotoxic phenotype with preferential involvement of the lymph nodes. Cases showing cutaneous presentation or with an immunosuppressive clinical history, while relatively common among typical γδ TCLs, are even rarer among this unusual CD4+ subset. While this very small group appears to have an equally dismal prognosis to other types of γδ TCL, little else is known as to how they may differ biologically and whether they should be treated as a separate entity. We report a unique case of CD4-positive gamma delta T cell lymphoma with skin and systemic lymph node involvement in the post-transplant setting.


γδ T cell lymphoma Nodal-based γδ T cell lymphoma CD4 Primary cutaneous γδ T cell lymphoma 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology, School of MedicineUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Pathology and Laboratory MedicineHenry Ford Health SystemDetroitUSA

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