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Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers

  • Aman Kumar
  • Niti Kumari
  • Nayudu Nallabelli
  • Rajendra PrasadEmail author
Review Article
  • 26 Downloads

Abstract

Histone modifications occupy an essential position in the epigenetic landscape of the cell, and their alterations have been linked to cancers. Histone 3 lysine 4 (H3K4) methylation has emerged as a critical epigenetic cue for the regulation of gene transcription through dynamic modulation by several H3K4 methyltransferases (writers) and demethylases (erasers). Any disturbance in the delicate balance of writers and erasers can result in the mis-regulation of H3K4 methylation, which has been demonstrated in several human cancers. Therefore, H3K4 methylation has been recognized as a putative therapeutic or prognostic tool and drug trials of different inhibitors of this process have demonstrated promising results. Henceforth, more detailed knowledge of H3K4 methylation is utmost important for elucidating the complex cellular processes, which might help in improving the disease outcome. The primary focus of this review will be directed on deciphering the role of H3K4 methylation along with its writers/erasers in different cancers.

Keywords

H3K4 methylation Histone methyltransferases Histone demethylases Prognosis Therapeutics Cancer 

Notes

Author’s Contribution

All authors are involved in the design, preparation of manuscript, read and final approval of the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest.

Ethical Approval

This is a review article and does not involve experiments with human subjects or animals performed by any of the authors.

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Copyright information

© Association of Clinical Biochemists of India 2019

Authors and Affiliations

  1. 1.Department of BiochemistryPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia
  2. 2.Department of EndocrinologyPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

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